{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:19:14Z","timestamp":1778721554246,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22fk0210065"],"award-info":[{"award-number":["JP22fk0210065"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23fk0210122"],"award-info":[{"award-number":["JP23fk0210122"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K15541"],"award-info":[{"award-number":["JP22K15541"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>The effect of direct\u2010acting antiviral agents (DAAs) on hepatocellular carcinoma (HCC) recurrence after curative hepatectomy remains uncertain. This retrospective study aimed to evaluate the effect of sustained virological response (SVR) with DAAs or interferon (IFN) therapy on recurrence and overall survival (OS) after hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 593 patients who underwent curative resections between January 2010 and December 2017. Among them, 186 achieved SVR before hepatectomy: a total of 51 (27.4%) in the DAA\u2010SVR group and 132 (72.6%) in the IFN\u2010based SVR group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SVR before hepatectomy was an independent predictor of OS, and the 5\u2010year OS rate was significantly higher in the SVR group than that in the non\u2010SVR group (82.2% vs. 63.9%). There were no significant differences in the recurrence rates or OS between DAA and IFN treatments in achieving SVR before hepatectomy, regardless of poor hepatic function in the DAA therapy group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no significant difference in OS and recurrence\u2010free survival (RFS) between the preoperative SVR achieved with DAA and IFN groups in this study, although liver function was significantly worse at the time of surgery in the DAA group compared to the IFN group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1406","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T05:20:05Z","timestamp":1703308805000},"page":"318-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of postoperative outcomes in cases achieving sustained virological response with direct\u2010acting antiviral and interferon therapy"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9617-4843","authenticated-orcid":false,"given":"Masakazu","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Hiroshima Prefectural Hospital  Hiroshima Japan"},{"name":"Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical &amp; Health Sciences Hiroshima University  Hiroshima Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7364-1798","authenticated-orcid":false,"given":"Tsuyoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical &amp; Health Sciences Hiroshima University  Hiroshima Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-5303","authenticated-orcid":false,"given":"Masahiro","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical &amp; Health Sciences Hiroshima University  Hiroshima Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Okimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Chugoku Rosai Hospital  Kure Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6859-7614","authenticated-orcid":false,"given":"Tomoyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Surgery JA Onomichi General Hospital  Onomichi Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Surgery National Hospital Organization Higashihiroshima Medical Center  Higashihiroshima Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Onoe","sequence":"additional","affiliation":[{"name":"Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer Center  Kure Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruhiko","family":"Honmyo","sequence":"additional","affiliation":[{"name":"Department of Surgery Hiroshima City North Medical Center, Asa Citizens Hospital  Hiroshima Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical &amp; Health Sciences Hiroshima University  Hiroshima Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ohdan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical &amp; Health Sciences Hiroshima University  Hiroshima Japan"},{"name":"HiSCO: Hiroshima Surgical study group of Clinical Oncology  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280632"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12896"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13236"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24663"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.034"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.043"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32111-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25352"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.029"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.08.030"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092674"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.050"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.21749"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903510963"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp052"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.12.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101158"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01541-18"},{"key":"e_1_2_8_26_1","article-title":"Trends and efficacy of interferon\u2010free anti\u2010hepatitis C virus therapy in the region of high prevalence of elderly patients, cirrhosis, and hepatocellular carcinoma: a real\u2010world, Nationwide, multicenter study of 10 688 patients in Japan. Open forum","volume":"6","author":"Toyoda H","year":"2019","journal-title":"Infect Dis"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.027"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.144878"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000245829.00977.45"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21415"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13503"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.1406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T10:43:54Z","timestamp":1716547434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.1406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/jhbp.1406"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.1406","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]},"assertion":[{"value":"2023-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}