{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:56:42Z","timestamp":1773795402318,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus infection due to contamination in large\u2010pool clotting factor concentrate is a major co\u2010morbidity in adult patients with hemophilia. Although the development of hepatocellular carcinoma following infection with hepatitis virus is a crucial health problem, there are few reports of hemophilia patients undergoing liver resection for hepatocellular carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six patients with hemophilia underwent liver resection for hepatocellular carcinoma in our department from <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2003 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012. We compared these hemophilic patients (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> group, <jats:italic>n<\/jats:italic> = 6) to control patients without hemophilia (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> group, <jats:italic>n<\/jats:italic> = 191) who underwent liver resection in the same period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All six patients in the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> group were hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus positive. Administration of coagulation factors was performed perioperatively, and no differences in the operative time and estimated blood loss were observed between the groups. No postoperative complications occurred in the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> group, but five patients suffered from recurrence after surgery and subsequently underwent radiofrequency ablation or transcatheter arterial chemoembolization. The median recurrence\u2010free survival time was 17.9 months and 25.3 months in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> group, respectively, with no significant difference between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adequate replacement of coagulation factors enables hepatic resection for hepatocellular carcinoma patients with hemophilia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.142","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:26:46Z","timestamp":1406852806000},"page":"824-828","source":"Crossref","is-referenced-by-count":11,"title":["Hepatectomy for hepatocellular carcinoma in patients with hemophilia"],"prefix":"10.1002","volume":"21","author":[{"given":"Yoshikuni","family":"Inokawa","sequence":"first","affiliation":[{"name":"Gastroenterological Surgery Nagoya University Graduate 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