{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:02:02Z","timestamp":1773280922097,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gallbladder carcinoma (GBC) and cholangiocarcinoma are aggressive forms of cancer developed in the gallbladder and biliary tracts which are related to the liver. This systematic review aimed to highlight the significant association between gallbladder, biliary cancers, and arsenic exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An extensive search was conducted in Embase, Cochrane, Scopus, PubMed, and Web of Science. We included studies that assessed arsenic levels in gallbladder cancer patients, without restrictions on age, sex, or language. Biological samples, such blood, bile, gallbladder tissue, gallstones, and hair were obtained, and arsenic levels were measured. Also, arsenic water and soil concentrations were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13 studies were included in our review. These studies included 2234 non\u2010gallbladder carcinoma patients and 22\u2009585 gallbladder carcinoma cases. The participant demographics showed a gender distribution of 862 males and 1845 females, with an age range of 20\u201375\u2009years. The average body mass index (BMI) was 19.8\u2009kg\/m<jats:sup>2<\/jats:sup> for nongallbladder carcinoma patients and 20.1\u2009kg\/m<jats:sup>2<\/jats:sup> for gallbladder carcinoma cases. The selected studies examined arsenic concentrations across various biological samples, including blood, hair, gallstones, and bile. Blood arsenic levels ranged from 0.0002 to 0.3893\u2009\u03bcg\/g and were significantly associated with increased gallbladder carcinoma risk in several studies. Hair also demonstrated a significant correlation, with arsenic concentrations ranging from 0.0002 to 6.9801\u2009\u03bcg\/g.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a strong link between arsenic exposure and gallbladder cancer or cholangiocarcinoma. Even chronic exposure to low\u2010moderate amounts could lead to gallbladder carcinoma. These findings stress the need for more comprehensive and dedicated studies, to control arsenic water\/soil levels and seek other preventive measures for this high mortality disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1428","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T03:28:39Z","timestamp":1712028519000},"page":"363-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Arsenic's shadowy influence: A systematic review of its carcinogenic role in gallbladder cancer"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4532-8574","authenticated-orcid":false,"given":"Anas","family":"Elgenidy","sequence":"first","affiliation":[{"name":"Faculty of Medicine Cairo University  Cairo Egypt"},{"name":"Karl\u2010Jaspers\u2010Klinik  Zwischenahn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3423-4055","authenticated-orcid":false,"given":"Ramez M.","family":"Odat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horiah Amer","family":"Al\u2010Ghorbany","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Helwan University  Helwan Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatim Nasruldin","family":"Shahin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine South Valley University  Qina Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim S.","family":"Abdel\u2010bary","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roaa AbdulTawab","family":"AbdulHamid","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Dhahab","sequence":"additional","affiliation":[{"name":"Faculty of medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moustafa","family":"Salem","sequence":"additional","affiliation":[{"name":"Faculty of medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youmna A.","family":"Negm","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada Mostafa","family":"El\u00a0Attar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Menofia University  Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Assem","family":"Abdelfattah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai M.","family":"Khaliel","sequence":"additional","affiliation":[{"name":"Faculty of medicine Alexandria university  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehab M.","family":"Moawad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Afifi","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Toledo Medical Center  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.157"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.26444\/aaem\/94299"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590500701201695"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10653\u2010008\u20109233\u20102"},{"key":"e_1_2_9_6_1","unstructured":"Guidelines for drinking\u2010water quality 2nd edition: Volume 2 \u2010 Health criteria and other supporting information. n.d.https:\/\/www.who.int\/publications\/i\/item\/9241544805. 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