{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:23:33Z","timestamp":1791307413727,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Although surgical resection is the only curative treatment for biliary tract cancer, in some cases, the disease is diagnosed as unresectable at initial presentation. There are few reports of conversion surgery after the initial treatment for unresectable locally advanced biliary tract cancer. This study aimed to evaluate the efficacy and safety of conversion surgery in patients with initially unresectable locally advanced biliary tract cancer.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively collected clinical data from groups of patients in multiple centers belonging to the Japanese Society of Hepato\u2010Biliary\u2010Pancreatic Surgery and Korean Association of Hepato\u2010Biliary\u2010Pancreatic Surgery. We analyzed two groups of prognostic factors (pretreatment and surgical factors) and their relation to the treatment outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 56 patients with initially unresectable locally advanced biliary tract cancer were enrolled in this study of which 55 (98.2%) patients received chemotherapy, and 16 (28.6%) patients received additional radiation therapy. The median time from the start of the initial treatment to resection was 6.4\u2009months. Severe postoperative complications of Clavien\u2010Dindo grade III or higher occurred in 34 patients (60.7%), and postoperative mortality occurred in five patients (8.9%). Postoperative histological results revealed CR in eight patients (14.3%). The median survival time from the start of the initial treatment in all 56 patients who underwent conversion surgery was 37.7\u2009months, the 3\u2010year survival rate was 53.9%, and the 5\u2010year survival rate was 39.1%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Conversion surgery for initially unresectable locally advanced biliary tract cancer may lead to longer survival in selected patients. However, more precise preoperative safety evaluation and careful postoperative management are required.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jhbp.1437","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T23:39:03Z","timestamp":1717198743000},"page":"481-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Conversion surgery for initially unresectable locally advanced biliary tract cancer: A multicenter collaborative study conducted in Japan and Korea"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1090-1614","authenticated-orcid":false,"given":"Yasuhiro","family":"Yabushita","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-9990","authenticated-orcid":false,"given":"Joon Seong","family":"Park","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Cancer Clinic, Department of Surgery, Gangnam Severance Hospital Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Surgery and Cancer Research Institute Seoul National College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7621-8557","authenticated-orcid":false,"given":"Yoo\u2010Seok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooil","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1593-3773","authenticated-orcid":false,"given":"Gi Hong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Surgical Oncology and Science Sapporo Medical University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3965-3693","authenticated-orcid":false,"given":"Ippei","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery, Department of Surgery Kindai University Faculty of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-544X","authenticated-orcid":false,"given":"Shugo","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusei","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sakata","sequence":"additional","affiliation":[{"name":"Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Kansai Rosai Hospital Amagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Gastroenterological Surgery Tokyo Women's Medical University Yachiyo Medical Center Yachiyo 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College of Medicine Ulsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea"},{"name":"Korean Association of Hepato\u2010Biliary\u2010Pancreatic Surgery (KAHBPS) Seoul South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6982-3457","authenticated-orcid":false,"given":"Hiroki","family":"Yamaue","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology Wakayama Medical University Wakayama Japan"},{"name":"Japanese Society of Hepato\u2010Biliary\u2010Pancreatic Surgery (JSHBPS) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Sup","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Surgery Yonsei University College of Medicine Seoul South Korea"},{"name":"Korean Association of Hepato\u2010Biliary\u2010Pancreatic Surgery (KAHBPS) Seoul South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Japanese Society of Hepato\u2010Biliary\u2010Pancreatic Surgery (JSHBPS) Tokyo Japan"},{"name":"Department of Surgery, Institute of Gastroenterology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongho","family":"Choi","sequence":"additional","affiliation":[{"name":"Korean Association of Hepato\u2010Biliary\u2010Pancreatic Surgery (KAHBPS) Seoul South\u00a0Korea"},{"name":"Department of Surgery, College of Medicine Hanyang University Seoul South 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University School of Medicine Yokohama Japan"},{"name":"Japanese Society of Hepato\u2010Biliary\u2010Pancreatic Surgery (JSHBPS) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00153-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301748"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908721"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz402"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.1219"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2312-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4768-9"},{"key":"e_1_2_8_9_1","first-page":"335","article-title":"Clinicopathological features of surgically\u2010resected biliary tract 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