{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:11:19Z","timestamp":1696403479583},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of recurrent hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> following liver transplantation remains a challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively investigated the efficacy and safety of simeprevir in combination with pegylated interferon and ribavirin in five patients undergoing living donor liver transplantation (<jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>) with recurrent hepatitis due to hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) genotype 1b.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As the immunosuppressive regimen, four received cyclosporine <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CsA<\/jats:styled-content>) and one received tacrolimus (<jats:styled-content style=\"fixed-case\">FK<\/jats:styled-content>); no dose adjustment was made prior to the introduction of simeprevir, but the dose was accordingly modified afterwards. All five patients completed the intended 12\u2010week treatment course without significant adverse events greater than grade 2, and no episodes of rejection were detected during the study period. The trough levels of <jats:styled-content style=\"fixed-case\">CsA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FK<\/jats:styled-content> were stably maintained. At week 12, <jats:styled-content style=\"fixed-case\">HCV\u2010RNA<\/jats:styled-content> was not detectable in three of the five patients, whereas the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> titer of the other two patients, including one with <jats:styled-content style=\"fixed-case\">Q80L<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">V170I<\/jats:styled-content> mutations at the <jats:styled-content style=\"fixed-case\">HCV NS3<\/jats:styled-content> position, was at the lower level of quantification (1.2 log<jats:sub>10<\/jats:sub> <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/ml).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on this pilot study, simeprevir\u2010based triple therapy is safe and somewhat effective within the first 12 weeks in <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> recipients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> recurrence. Further studies are warranted to obtain robust conclusions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.171","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:06:29Z","timestamp":1414022789000},"page":"144-150","source":"Crossref","is-referenced-by-count":10,"title":["Use of simeprevir following pre\u2010emptive pegylated interferon\/ribavirin treatment for recurrent hepatitis <scp>C<\/scp> in living donor liver transplant recipients: a 12\u2010week pilot study"],"prefix":"10.1002","volume":"22","author":[{"given":"Tomohiro","family":"Tanaka","sequence":"first","affiliation":[{"name":"Organ Transplantation Service The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumihito","family":"Tamura","sequence":"additional","affiliation":[{"name":"Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Aoki","sequence":"additional","affiliation":[{"name":"Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namiki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Kokudo","sequence":"additional","affiliation":[{"name":"Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 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