{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:59:42Z","timestamp":1787590782923,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adult pyogenic liver abscess (<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>) is a major hepato\u2010biliary infection. We aim to identify risk factors associated with therapy failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of 741 <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content> patients (2001\u20132011) and comparison with earlier data (1994\u20131997). Risk factors associated with therapy failure were identified with multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incidence of <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content> is 86\/100\u2009000 admissions, with average size 5.75\u2009cm. 68% of <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content> were secondary to <jats:italic><jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lebsiella pneumoniae<\/jats:italic> and there is increasing extended\u2010spectrum beta\u2010lactamase (<jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>) resistance. Compared with 1990s, there is an increasing annual incidence (from 18 to 67). Elderly age (\u226555\u2010years\u2010old), presence of multiple abscesses, malignancy as etiology and patients who underwent endoscopic intervention are independent predictors for failure of antibiotics\u2010only therapy while average intravenous antibiotics duration and average abscess size are not. <jats:styled-content style=\"fixed-case\">ECOG<\/jats:styled-content> performance status \u22652, pre\u2010existing hypertension and hyperbilirubinaemia are independent predictors for failure of percutaneous therapy while the presence of multiple abscesses and average abscess size are not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is an increasing <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content> incidence with increasing <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content> resistance. Percutaneous drainage should be considered early for elderly patients (\u226555\u2010years\u2010old), with multiple abscesses, malignancy as etiology or who required endoscopic intervention. We should have a low threshold for surgical intervention for patients with <jats:styled-content style=\"fixed-case\">ECOG<\/jats:styled-content> performance status \u22652, co\u2010morbidity of hypertension or hyperbilirubinaemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.174","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:06:55Z","timestamp":1414022815000},"page":"156-165","source":"Crossref","is-referenced-by-count":76,"title":["Predictors of therapy failure in a series of 741 adult pyogenic liver abscesses"],"prefix":"10.1002","volume":"22","author":[{"given":"Joseph Zhi Wen","family":"Lo","sequence":"first","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  11 Jalan Tan Tock Seng Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey Jia Jun","family":"Leow","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  11 Jalan Tan Tock Seng Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perryn Ling Fei","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  11 Jalan Tan Tock Seng Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Qi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  11 Jalan Tan Tock Seng Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Alia","family":"Mohd Noor","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  11 Jalan Tan Tock Seng Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Keem","family":"Low","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  11 Jalan Tan Tock Seng Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer P.","family":"Junnarkar","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  11 Jalan Tan Tock Seng Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston Wei Liang","family":"Woon","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  11 Jalan Tan Tock Seng Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(38)90618-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004116606"},{"key":"e_1_2_7_4_1","first-page":"228","article-title":"Factors influencing mortality in the treatment of pyogenic hepatic abscess","volume":"140","author":"Pitt HA","year":"1975","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750910"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90382-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90381-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400050072009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1991.01410320077010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.824.436"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199605000-00016"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.1999.01523.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00564-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.12.797"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/425616"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00459-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02487.x"},{"key":"e_1_2_7_18_1","first-page":"282","article-title":"Pyogenic liver abscesses: a study of 25 cases","volume":"84","author":"Beyrouti MI","year":"2006","journal-title":"Tunis Med"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282eeb53b"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.01.016"},{"key":"e_1_2_7_21_1","first-page":"417","article-title":"Pyogenic liver abscesses","volume":"103","author":"T\u00e2rcoveanu E","year":"2008","journal-title":"Chirurgia (Bucur)"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-10182009000100007"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.614"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i12.1622"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/316013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050194"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02787.x"},{"key":"e_1_2_7_29_1","first-page":"250","article-title":"A clinical study of pyogenic liver abscess at two different local hospitals","volume":"11","author":"Jun DW","year":"2005","journal-title":"Korean J Hepatol"},{"key":"e_1_2_7_30_1","first-page":"196","article-title":"Predictors of mortality in patients with pyogenic liver abscess","volume":"66","author":"Chen SC","year":"2008","journal-title":"Neth J Med"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1410.071254"},{"key":"e_1_2_7_32_1","first-page":"483","article-title":"Pyogenic liver abscess: clinical profile, microbiological characteristics, and management in a Hong Kong hospital","volume":"41","author":"Lok KH","year":"2008","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.08.022"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01285.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-010-0103-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2173"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000154265.14006.47"},{"key":"e_1_2_7_38_1","first-page":"1158","article-title":"Management of pyogenic liver abscesses\u2014percutaneous or open drainage?","volume":"48","author":"Chung YF","year":"2007","journal-title":"Singapore Med J"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.09.051"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199012000-00002"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199603000-00006"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1104"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.747"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.09.016"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146.ch4"},{"key":"e_1_2_7_46_1","unstructured":"Ministry of Health Singapore.Statistics of disease burden in Singapore. Available from:http:\/\/www.moh.gov.sg\/content\/moh_web\/home\/statistics\/Health_Facts_Singapore\/Disease_Burden.html."},{"key":"e_1_2_7_47_1","first-page":"489","article-title":"Pyogenic liver abscess\u2014a tropical centre's experience in management with review of current literature","volume":"41","author":"Liew KV","year":"2000","journal-title":"Singapore Med J"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/513201"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2010.16.2.131"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.586"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.3.242"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i20.2458"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200701020-00012"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2423051344"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31812f59c7"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-009-0695-7"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030857"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1086\/499968"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.11.008"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70205-0"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12027"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.05.022"},{"key":"e_1_2_7_63_1","first-page":"183","article-title":"Pyogenic liver abscess\u2014predicting failure to improve outcome","volume":"66","author":"Chung YF","year":"2008","journal-title":"Neth J Med"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480807400219"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjhbp.174","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:50:48Z","timestamp":1696369848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/jhbp.174"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.174","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}