{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T16:45:15Z","timestamp":1708015515791},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:00:00Z","timestamp":1414022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Splenectomy is a therapy for thrombocytopenia caused by hypersplenism with liver cirrhosis. However, the determinant of therapeutic outcomes for this complication has not yet been fully clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the laboratory findings of 55 patients who underwent splenectomy for hypersplenism with liver cirrhosis. In addition, we examined the histopathological findings of hepatosplenic tissues of nine patients who underwent hepatectomy for hepatocellular carcinoma and splenectomy for hypersplenism with liver cirrhosis on one stage surgery. The locations of platelets in hepatosplenic tissues were identified by immunohistochemistry. We used monoclonal antibody against <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>41.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 55 patients, 40 patients had high serum alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) level (\u226738\u2009IU\/l). Blood platelet count after splenectomy of patients with high serum <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> level were significantly lower than those of patients with low serum <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> level (<jats:italic>P<\/jats:italic> = 0.02). Histopathologically, platelet area of the liver tissues was positively correlated with hepatic inflammation (<jats:italic>P<\/jats:italic> = 0.02). Platelet area of the liver tissues was negatively correlated with blood platelet count after splenectomy (<jats:italic>P<\/jats:italic> = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hepatic inflammation contributes to the accumulation of platelets in liver; therefore, in patients with high serum <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> level, improvement of thrombocytopenia by the elimination of hypersplenism was limited.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.177","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:17:42Z","timestamp":1414109862000},"page":"217-224","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic efficacy of splenectomy is attenuated by necroinflammation of the liver in patients with liver cirrhosis"],"prefix":"10.1002","volume":"22","author":[{"given":"Reiichiro","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  67 Asahi\u2010machi Kurume Fukuoka 830\u20100011 Japan"},{"name":"Cancer Center Kurume University Hospital  Kurume Fukuoka Japan"},{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Kage","sequence":"additional","affiliation":[{"name":"Cancer Center Kurume University Hospital  Kurume Fukuoka Japan"},{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Surgery Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Kurume University Hospital  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  67 Asahi\u2010machi Kurume Fukuoka 830\u20100011 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriko","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  67 Asahi\u2010machi Kurume Fukuoka 830\u20100011 Japan"},{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  67 Asahi\u2010machi Kurume Fukuoka 830\u20100011 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