{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:40:14Z","timestamp":1696603214379},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There has existed important differences in the definition of acute liver failure (<jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>) between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese criteria and those of other countries. The novel diagnostic criteria for <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients were established by the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ntractable <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>epato\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>iliary <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iseases <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup of <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan, in order to correspond to those for <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>urope and the USA. We prospectively diagnosed our <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> patients based on this novel criteria, and discussed the etiology by a fixed point observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the etiology of 54 adult inpatients and outpatients with <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> between 2010 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 54 patients, 36 were <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> without coma, 17 <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> with coma and one late onset hepatic failure. The etiology was due to viral infections in 38.9%, autoimmune hepatitis in 11.1%, drug\u2010induced liver injury in 13.0%, etiologies without hepatitis in 29.6% (circulatory disturbance in 18.5%, infiltration of the liver by malignant cells in 7.4%, and metabolic diseases in 3.7%) and indeterminate causes in 7.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Circulatory disturbance was the most frequent etiology according to the novel criteria. Indeterminate etiology was less observed in our study than the nation\u2010wide survey with significance (<jats:italic>P<\/jats:italic> = 0.0014).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.178","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:07:42Z","timestamp":1414022862000},"page":"225-229","source":"Crossref","is-referenced-by-count":5,"title":["Fixed point observation of etiology of acute liver failure according to the novel <scp>J<\/scp>apanese diagnostic criteria"],"prefix":"10.1002","volume":"22","author":[{"given":"Keiichi","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yonemitsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Division of Pathology Ofuna Chuo Hospital  Kamakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yokosuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"The Proceedings of the 12th Inuyama Symposium. 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