{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:21:17Z","timestamp":1775607677501,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It was recently reported that alkaline phosphatase (ALP) levels below 1.5 upper limit of normal (ULN) predicted better prognosis in primary sclerosing cholangitis (PSC). We evaluated whether ALP as well as other laboratory values were useful for the short\u2010term prognosis of PSC in a Japanese cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 78 patients with PSC (41 males and 37 females, mean onset age 41.9 years), the relationship between nine parameters (albumin, bilirubin, international normalized ratio of prothrombin time [PT\u2010INR], ALP, aspartate aminotransferase [AST], alanine aminotransferase [ALT], \u03b3\u2010glutamyl transpeptidase [\u03b3\u2010GTP], platelet, and calculated Model for End\u2010Stage Liver Disease [MELD] score), and liver related clinical endpoints (death due to liver failure, variceal bleeding, liver transplantation, and biliary carcinoma) were retrospectively examined. Using receiver operating characteristic (ROC) analysis, we investigated which parameter was useful for predicting the short\u2010term prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average follow\u2010up period was 8.6 years. The endpoints were evaluated in 40 patients. Seven patients died of liver failure, three patients developed variceal bleeding, nine patients received liver transplantation from a living donor, 13 patients received certified brain\u2010dead liver transplantation, and eight patients developed biliary carcinoma. The parameters with an area under the curve (AUC) of more than 0.8 were albumin, bilirubin, PT\u2010INR, ALP, and MELD score. AUC for ALP was 0.85. The optimal cutoff value was 2.3 ULN. Despite the use or non\u2010use of ursodeoxycholic acid, short\u2010term prognosis of patients with an ALP level below 2.3 ULN was good.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We confirmed that keeping ALP low is associated with better short\u2010term prognosis in a Japanese cohort. In addition, Alb, Bil, PT\u2010INR, and MELD score were good predictors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.238","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T03:30:56Z","timestamp":1427859056000},"page":"486-490","source":"Crossref","is-referenced-by-count":17,"title":["Short\u2010term prognostic factors for primary sclerosing cholangitis"],"prefix":"10.1002","volume":"22","author":[{"given":"Takeo","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Kanto Central Hospital of the Mutual Aid Association of Public School Teachers  6\u201325\u20131 Kamiyouga, Setagaya\u2013ku Tokyo 158\u20138531 Japan"},{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Gastroenterology Tokyo Takanawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Isayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Gastroenterology Toshiba General Hospital  Tokyo 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