{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:14:54Z","timestamp":1778638494776,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Center Research and Development Fund","award":["25-A-3"],"award-info":[{"award-number":["25-A-3"]}]},{"name":"Ministry of Health, Labour and Welfare of Japan","award":["23-011"],"award-info":[{"award-number":["23-011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to examine the associations between postoperative clinicopathological features of intraductal papillary mucinous neoplasm (IPMN) and recurrence over a long follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed 153 IPMN patients who underwent resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The resected tumors showed low\/intermediate\u2010grade dysplasia (LGD\/IGD), high\u2010grade dysplasia (HGD), T1a (stromal invasion \u22645\u2009mm), and invasive intraductal papillary mucinous carcinoma (IPMC), in 54.9%, 22.2%, 4.6%, and 18.3% of patients, respectively. The median follow\u2010up period after surgery was 46.4 (6.0\u2013216.3) months, with an overall recurrence rate of 17.0%; the recurrence rates by histological type were 6.0%, 5.9%, 42.9%, and 57.1% for LGD\/IGD, HGD, T1a, and invasive IPMC, respectively. Multivariate analysis revealed that recurrences related with tumor location, mural nodule size, presence of invasive cancer, lymph node metastasis, IPMN in the remnant pancreas, and main pancreatic duct dilatation after surgery. Recurrence occurred within the remnant pancreas in all LGD\u2010T1a patients and as extrapancreatic metastasis in all patients with invasive IPMC. Of the total recurrences, 15.4% occurred over 5\u2009years postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The postoperative follow\u2010up protocol for patients with LGD\u2010T1a should be similar to non\u2010resected IPMN, and that for invasive IPMC should be the same as for pancreatic ductal adenocarcinoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.280","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T05:46:21Z","timestamp":1435988781000},"page":"757-765","source":"Crossref","is-referenced-by-count":36,"title":["Risk factors for postoperative recurrence of intraductal papillary mucinous neoplasms of the pancreas based on a long\u2010term follow\u2010up study: proposals for follow\u2010up strategies"],"prefix":"10.1002","volume":"22","author":[{"given":"Tatsuji","family":"Yogi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Aichi Cancer Center Hospital  Nagoya 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