{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T07:10:18Z","timestamp":1696057818939},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To identify prognostic factors prospectively in cirrhosis after the eradication of esophageal varices (EV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>There were 52 cirrhosis patients (Child\u2013Pugh A 24, B 28) who showed the eradication of EV after the endoscopic sclerotherapy (median observation period, 25.5\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients showed a recurrence of EV. The cumulative overall survival rate was 92.2% at 1\u2009year, 70.9% at 3\u2009years, and 47.2% at 5\u2009years. Univariate analysis showed that serum sodium concentration (hazard ratio [HR] 0.724, <jats:italic>P<\/jats:italic> = 0.0006), serum aspartate transaminase (HR 1.019, <jats:italic>P<\/jats:italic> = 0.0075), serum alanine transaminase (HR 1.025, <jats:italic>P<\/jats:italic> = 0.0239), and serum creatinine (HR 11.311, <jats:italic>P<\/jats:italic> = 0.044) levels before treatment were significant factors for a poor prognosis. Multivariate analysis revealed that serum sodium concentration (HR 0.711, <jats:italic>P<\/jats:italic> = 0.0022) was the only significant factor. The cumulative survival rate was lower in patients with hyponatremia (&lt;135\u2009mEq\/l, a best cut\u2010off value; 83.3% at 1\u2009year, and 33.3% at 3\u2009years), than in those without (93.3% at 1\u2009year, 77.3% at 3\u2009years and 47.2% at 5\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010treatment hyponatremia is a significant prognostic factor in cirrhosis with Child A\/B after the eradication of EV by the endoscopic sclerotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.282","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T02:37:46Z","timestamp":1437619066000},"page":"771-778","source":"Crossref","is-referenced-by-count":1,"title":["Hyponatremia: a significant factor in a poor prognosis for cirrhosis with Child A\/B after variceal eradication"],"prefix":"10.1002","volume":"22","author":[{"given":"Hitoshi","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  1\u20108\u20101 Inohana, Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  1\u20108\u20101 Inohana, Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Sekimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  1\u20108\u20101 Inohana, Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Kiyono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  1\u20108\u20101 Inohana, Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  1\u20108\u20101 Inohana, Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  1\u20108\u20101 Inohana, Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Okugawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  1\u20108\u20101 Inohana, Chuo\u2010ku Chiba 260\u20108670 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