{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:49:07Z","timestamp":1790293747421,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T00:00:00Z","timestamp":1455667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is, as yet, no gold standard for making the diagnosis of acute onset autoimmune hepatitis (A\u2010AIH). Novel histological characteristics have been reported, but etiologies other than AIH could show similar histological pattern. We attempted to determine what clinical characteristics we should consider as A\u2010AIH different from other etiologies, and to whom histological characteristics should be applied for the diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical, biochemical, immunological and pathological features of 46 patients (35 women, mean age 55.9\u00a0\u00b1\u00a014.2\u00a0years) with non\u2010severe A\u2010AIH admitted to a community hospital between 2001 and 2015 were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunoglobulin G level was normal in 28%, and anti\u2010nuclear antibody titer was &lt; \u00d7 80 in 28%. Liver histology of 49% showed acute form and 51% chronic one. Centrilobular necrosis\/collapse and\/or plasma cell accumulation, rosette formation were characteristic for A\u2010AIH. High levels of alanine aminotranferase persisted in 21 patients who could be observed for equal to or more than 4\u00a0weeks before the start of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long persistence of high levels of alanine aminotransferase would be one of clinical features for considering A\u2010AIH along with conventional features. Histological diagnostic features should be applied for such patients. Guidelines for diagnosing A\u2010AIH should be urgently drawn up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.319","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T17:37:05Z","timestamp":1452533825000},"page":"174-180","source":"Crossref","is-referenced-by-count":8,"title":["High level of persistent liver injury is one of clinical characteristics in treatment\u2010na\u00efve acute onset autoimmune hepatitis: experience in a community hospital"],"prefix":"10.1002","volume":"23","author":[{"given":"Keiichi","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Nephrology, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku, Chiba 260\u20108670 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Seikeikai Chiba Medical Center  Chiba 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