{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:17:59Z","timestamp":1776061079583,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T00:00:00Z","timestamp":1463270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The natural history of human T\u2010cell leukemia virus type 1 (HTLV\u20101), which causes adult T\u2010cell leukemia (ATL) or HTLV\u20101 associated myelopathy, after liver transplantation is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nationwide survey to investigate the impact of HTLV\u20101 status on living donor liver transplantation (LDLT) in Japan. We analyzed the cases of 82 HTLV\u20101\u2010positive recipients and six HTLV\u20101\u2010negative\u2010before\u2010LDLT recipients who received a hepatic graft from HTLV\u20101\u2010positive donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adult T\u2010cell leukemia developed in five recipients who ultimately died. Of these five, two received grafts from HTLV\u20101\u2010positive donors and three from HTLV\u20101\u2010negative donors. The 1\u2010, 3\u2010, and 5\u2010year ATL development rates were 4.5%, 6.5%, and 9.2%, respectively. Fulminant hepatic failure as a pre\u2010transplant diagnosis was identified as an independent risk factor for ATL development (<jats:italic>P<\/jats:italic> = 0.001). The 1\u2010, 3\u2010, and 5\u2010year survival rates for HTLV\u20101\u2010positive recipients who received grafts from HTLV\u20101\u2010negative donors were 79.9%, 66.1%, and 66.1%, and from HTLV\u20101\u2010positive donors were 83.3%, 83.3%, and 60.8%, respectively. The 1\u2010year survival rate for HTLV\u20101\u2010negative recipients who received grafts from HTLV\u20101\u2010positive donors was 33.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fulminant hepatic failure is an independent risk factor for ATL development in HTLV\u20101\u2010positive recipients. Grafts from HTLV\u20101\u2010positive living donors can be transplanted into selected patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.345","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T07:46:56Z","timestamp":1458546416000},"page":"333-341","source":"Crossref","is-referenced-by-count":16,"title":["Impact of human T\u2010cell leukemia virus type 1 on living donor liver transplantation: a multi\u2010center study in Japan"],"prefix":"10.1002","volume":"23","author":[{"given":"Tomoharu","family":"Yoshizumi","sequence":"first","affiliation":[{"name":"Department of Surgery and Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutsugu","family":"Takada","sequence":"additional","affiliation":[{"name":"The Study Group of the Japanese Society of Hepato\u2010biliary\u2010Pancreatic Surgery and Japanese Liver Transplantation Society  Tokyo 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