{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:00:40Z","timestamp":1784671240106,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T00:00:00Z","timestamp":1494720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japanese Society of Hepato-Biliary-Pancreatic Surgery"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since the publication of the Tokyo Guidelines (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>13) for the management of acute cholecystitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>), multidirectional studies have been published. However, epidemiological research about <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> with big data was not projected. The aim of this study was to reveal the actual clinical conditions of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study was designed as an international multicenter retrospective study of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> in Japan and Taiwan from 2011 to 2013. The factors investigated comprised data related to demographic, history, physical examinations, laboratory and imaging findings. Based on these data, we investigated the various values of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, and real situation with respect to severity and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5,459 patients with <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> were reviewed. Thirty\u2010day mortality rate was 1.1%. Based on the diagnostic criteria, 4,088 patients had a definite diagnosis and 291 had a suspected diagnosis. According to the severity grading, 939 patients were classified as Grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, 2,308 as Grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and 2,130 as Grade I. Cholecystectomy was performed in total of 4,266 patients and 2,765 patients had laparoscopic cholecystectomy. The main etiologies were gallbladder stones in 4,623 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This epidemiological study with large population will undoubtedly contribute to establish the best practice for managing <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> worldwide.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.450","type":"journal-article","created":{"date-parts":[[2017,3,19]],"date-time":"2017-03-19T05:59:39Z","timestamp":1489903179000},"page":"319-328","source":"Crossref","is-referenced-by-count":38,"title":["Descriptive review of acute cholecystitis: Japan\u2010Taiwan collaborative epidemiological study"],"prefix":"10.1002","volume":"24","author":[{"given":"Masamichi","family":"Yokoe","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine Japanese Red Cross Nagoya Daini Hospital Aichi 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