{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:43:39Z","timestamp":1773823419400,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2015R1A5A6001906"],"award-info":[{"award-number":["2015R1A5A6001906"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We built a multinational retrospective database of patients with ampulla of Vater cancer to develop a reliable new staging system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study included 841 patients with ampulla of Vater cancer after curative surgery at Seoul National University Hospital (<jats:italic>n<\/jats:italic>\u00a0=\u00a0440) and Johns Hopkins University medical institutions (<jats:italic>n<\/jats:italic>\u00a0=\u00a0401) between 1985 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) rates of patients staged according to the 7<jats:sup>th<\/jats:sup> American Joint Committee on Cancer staging system were 80.3%, 60.9%, 58.1%, 36.6%, 17.9%, and 25.0% for Stages <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0140), <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0194), <jats:styled-content style=\"fixed-case\">IIA<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0115), <jats:styled-content style=\"fixed-case\">IIB<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0348), <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a033), and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), respectively. Five\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates were similar in patients with Stage <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> (T2N0M0) and <jats:styled-content style=\"fixed-case\">IIA<\/jats:styled-content> (T3N0M0) tumors (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.556), but differed significantly between other pairs of groups. The number of positive lymph nodes (<jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>) enhanced prognosis when stratified as 0, 1\u20132 and \u22653 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The revised staging system consisted of Stages I (T1, <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> 0), <jats:styled-content style=\"fixed-case\">IIA<\/jats:styled-content> (T2\u2013T3, <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> 0), <jats:styled-content style=\"fixed-case\">IIB<\/jats:styled-content> (T1\u2013T3, <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> 1\u20132), <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> \u22653 or any T4), and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> (any M1), with 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates differing significantly in each pair of groups, including Stages I and <jats:styled-content style=\"fixed-case\">IIA<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This new staging system has better discriminatory ability in stratifying 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates based on a large multinational database.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.486","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T07:52:39Z","timestamp":1498722759000},"page":"475-484","source":"Crossref","is-referenced-by-count":5,"title":["Proposed new staging system for ampulla of Vater cancer with greater discriminatory ability: multinational study from eastern and western centers"],"prefix":"10.1002","volume":"24","author":[{"given":"Jin","family":"He","sequence":"first","affiliation":[{"name":"Department of Surgery Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Ri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Yeoun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Sejong University College of Natural Sciences Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinseok","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Sejong University College of Natural Sciences Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taesung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Statistics Seoul National University College of Natural Sciences Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mee 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