{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:57:06Z","timestamp":1792591026017,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In cases of acute cholecystitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>), postoperative antibiotic prophylaxis is generally used for the purpose of preventing subsequent infections. However, there is still no standardized guideline regarding antibiotic administration after cholecystectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 200 patients at five participating hospitals who were admitted for cholecystectomy to treat grade I or <jats:styled-content style=\"fixed-case\">II AC<\/jats:styled-content> were enrolled and randomly allocated to a group given a placebo (group A) or a group given postoperative antibiotics (group B). Surgical outcomes and incidence of postoperative infectious morbidities were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 188 patients (95 patients in group A and 93 patients in group B) were finally analyzed. The incidence rate of infectious complications (seven cases, 7.4%, in group A and eight cases, 8.6%, in group B, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.794) and overall non\u2010infectious complications (seven cases, 7.4%, in group A and six cases, 6.5%, in group B, <jats:italic>P\u00a0=\u00a0<\/jats:italic>1.000) showed no significant difference between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Absence of postoperative antibiotic administration did not lead to an increase in postoperative infections in cases of mild to moderate <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>. Avoidance of unnecessary antibiotic use will reduce the adverse effects of antibiotics and also allow for a tailored treatment strategy according to the severity of cholecystitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.495","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T16:26:40Z","timestamp":1502987200000},"page":"550-558","source":"Crossref","is-referenced-by-count":18,"title":["Is there a real role of postoperative antibiotic administration for mildmoderate acute cholecystitis? A prospective randomized controlled trial"],"prefix":"10.1002","volume":"24","author":[{"given":"Eun Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Trauma and Surgical Critical Care Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Chul","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010biliary and Pancreas Surgery Incheon St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Joong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010biliary and Pancreas Surgery Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010biliary and Pancreas Surgery Uijeongbu St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010biliary and Pancreas Surgery St. Paul's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010biliary and Pancreas Surgery Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul 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