{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:35:24Z","timestamp":1776490524242,"version":"3.51.2"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["23\u20102016\u20100060"],"award-info":[{"award-number":["23\u20102016\u20100060"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal surgical extent for T1 gallbladder cancer (<jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content>) remains controversial. Simple cholecystectomy is routinely performed for T1 <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> while several guidelines recommend extended cholecystectomy for T1b <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content>. However, evidence regarding the optimal surgical extent for T1 <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> is lacking. This study aims to systematically evaluate the optimal surgical extent for early <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> with regard to long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search in <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> was performed to identify studies with histologically proven <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> and survival data. A total of 22 articles with a total of 2,578 patients were included in the final analysis. Dichotomous data regarding cancer\u2010related death in all T1, T1a, and T1b <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> cases were extracted. Risk ratios, risk differences, and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were pooled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk ratio between simple and extended cholecystectomy in T1 <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> patients was 1.06 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.97\u20131.16); T1a, 0.82 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.70\u20130.96); and T1b, 1.06 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.93\u20131.22). No significant difference was found according to the extent of surgery in all T1 or T1b <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> cases (<jats:italic>P<\/jats:italic> = 0.17 and <jats:italic>P<\/jats:italic> = 0.36, respectively). Simple cholecystectomy had significantly lower cancer\u2010related death in T1a <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simple and extended cholecystectomy showed comparable survival outcomes in T1 <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.521","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T21:56:40Z","timestamp":1510178200000},"page":"131-141","source":"Crossref","is-referenced-by-count":47,"title":["Optimal extent of surgery for early gallbladder cancer with regard to long\u2010term survival: a meta\u2010analysis"],"prefix":"10.1002","volume":"25","author":[{"given":"Hongeun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University 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