{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:51:34Z","timestamp":1778709094741,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Among biliary atresia (BA<\/jats:styled-content>) patients undergoing revision following failed portoenterostomy, long\u2010term native liver survival (NLS<\/jats:styled-content>), physical condition, and indications for revision were explored.<\/jats:p><\/jats:sec>Methods<\/jats:title>From 1977\u20132015, 33 of 95 BA<\/jats:styled-content> patients (35%) at our institution underwent revision. Ten\u2010 and 20\u2010year NLS<\/jats:styled-content> rates (NLSR<\/jats:styled-content>s) and biochemical statuses of 20\u2010year\u2010old native liver survivors were compared between post\u2010portoenterostomy BA<\/jats:styled-content> patients with and without history of revision. Factors associated with 10\u2010year NLS<\/jats:styled-content> following revision and optimal cut\u2010offs for potential predictors were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall 10\u2010 and 20\u2010year NLSR<\/jats:styled-content>s were 57% and 54%, respectively. Ten\u2010 and 20\u2010year NLSR<\/jats:styled-content>s were 49% and 45% in the revision group and 63% and 61% in the non\u2010revision group, respectively. Among 20\u2010year\u2010old native liver survivors, differences in admission rates between ages 10\u201320 years were not significant for cholangitis (revision, 46%; non\u2010revision, 40%; P<\/jats:italic> = 0.30) or portal hypertension (revision, 38%; non\u2010revision, 15%; P<\/jats:italic> = 0.21). Differences in hepatobiliary function\u2010associated blood tests between these groups at 20 years old were only significant for aspartate aminotransferase (P<\/jats:italic> = 0.02) and gamma\u2010glutamyl transpeptidase (P<\/jats:italic> = 0.047). Among potential predictors of 10\u2010year NLS<\/jats:styled-content> that we investigated, rate of change in total bilirubin (TB<\/jats:styled-content>) over the first month post\u2010portoenterostomy was best (P<\/jats:italic> = 0.0019), and the receiver operating characteristic curve revealed an optimal cut\u2010off for this first\u2010month change in TB<\/jats:styled-content> of \u22123.7 mg\/dl (area under the curve, 0.85; sensitivity, 0.79; specificity, 0.83).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In approximately half of the patients, revision provided 10\u2010 and 20\u2010year NLS<\/jats:styled-content>, and biochemical status at 20 years old was comparable across revision and non\u2010revision patients. Rate of change in TB<\/jats:styled-content> during the first month post\u2010portoenterostomy offers a sensitive predictor of revision.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.548","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:16:43Z","timestamp":1521991003000},"page":"275-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Significance and indications for reoperative portoenterostomy in biliary atresia in light of long\u2010term outcome"],"prefix":"10.1002","volume":"25","author":[{"given":"Takeshi","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery (E6) Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Terui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery (E6) Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Mitsunaga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery (E6) Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyuki","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery (E6) Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shugo","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery (E6) Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery (E6) Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3396-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12676"},{"key":"e_1_2_6_4_1","first-page":"291","article-title":"Japanese biliary atresia registry 2014","volume":"52","author":"Japanese Society for Biliary Atresia","year":"2016","journal-title":"J Jpn Soc Pediatr Surg"},{"key":"e_1_2_6_5_1","first-page":"192","article-title":"Impact of previous multiple portoenterostomies on living donor liver transplantation for biliary atresia","volume":"51","author":"Sugawara Y","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2012.0188"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318243a46e"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.395"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.09.049"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-002-0846-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181aaccb0"},{"key":"e_1_2_6_12_1","first-page":"1013","article-title":"The Declaration of Istanbul on organ trafficking and transplant tourism","volume":"2008","author":"Participants in the International Summit on Transplant Tourism and Organ Trafficking Convened by the Transplantation Society and International Society of Nephrology in Istanbul, Turkey, April 30\u2010May 2","year":"2008","journal-title":"Transplantation"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjhbp.548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:45:12Z","timestamp":1695501912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,12]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/jhbp.548"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.548","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,12]]},"assertion":[{"value":"2018-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}