{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:58:28Z","timestamp":1773255508379,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Whether non\u2010colorectal non\u2010neuroendocrine liver metastasis (\n                      <jats:styled-content style=\"fixed-case\">NCNNLM<\/jats:styled-content>\n                      ) should be treated surgically remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data regarding 1,639 hepatectomies performed between 2001 and 2010 for 1,539 patients with\n                      <jats:styled-content style=\"fixed-case\">NCNNLM<\/jats:styled-content>\n                      were collected from 124 institutions. Patient characteristics, types of primary tumor, characteristics of liver metastases, and post\u2010hepatectomy outcomes were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The five most frequent primary tumors were gastric carcinoma (540 patients [35%]), gastrointestinal stromal tumor (204 patients [13%]), biliary carcinoma (150 patients [10%]), ovarian cancer (107 patients [7%]), and pancreatic carcinoma (77 patients [5%]). R0\/1 hepatectomy was achieved in 90% of patients, with 1.5% in\u2010hospital mortality rate. Overall and disease\u2010free survival rates of 1,465 patients included in survival analysis were 41% and 21%, respectively, at 5\u00a0years, and 28% and 15%, respectively, at 10\u00a0years. Five\u2010year survival associated with the five frequent primary tumors were 32%, 72%, 17%, 52%, and 31%, respectively, and factors predictive of a poor outcome differed by the primary tumor type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our data indicated that hepatectomy is safe for\n                      <jats:styled-content style=\"fixed-case\">NCNNLM<\/jats:styled-content>\n                      and that patient prognoses vary depending on the type of primary tumors. Indications for hepatectomy should be determined with reference to survival rates and risk factors specific to each of the various types of primary tumor.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.587","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T06:55:14Z","timestamp":1539327314000},"page":"465-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Outcomes of 1,639 hepatectomies for non\u2010colorectal non\u2010neuroendocrine liver metastases: a multicenter analysis"],"prefix":"10.1002","volume":"25","author":[{"given":"Keiji","family":"Sano","sequence":"first","affiliation":[{"name":"Department of Surgery Teikyo University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Institute of Gastroenterology Tokyo Women's Medical University Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsushige","family":"Mimura","sequence":"additional","affiliation":[{"name":"Department of Surgery Okayama Saiseikai General Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Nakamori","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary\u2010Pancreatic Surgery National Hospital Organization Osaka National Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary\u2010Pancreatic Surgery National Cancer 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