{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:33:42Z","timestamp":1788262422291,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no consensus on the optimal treatment of T1b gallbladder cancer (GBC) due to the lack of evidence and the difficulty of anatomy and pathological standardization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 272 patients with T1b GBC who underwent surgical resection at 14 centers with specialized hepatobiliary\u2010pancreatic surgeons and pathologists in Korea, Japan, Chile, and the United States were studied. Clinical outcomes including disease\u2010specific survival (DSS) rates according to the types of surgery were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After excluding patients, the 237 qualifying patients consisted of 90 men and 147 women. Simple cholecystectomy (SC) was performed in 116 patients (48.9%) and extended cholecystectomy (EC) in 121 patients (51.1%). The overall 5\u2010year DSS was 94.6%, and it was similar between SC and EC patients (93.7% vs. 95.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.496). The 5\u2010year DSS was similar between SC and EC patients in America (82.3% vs. 100.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.249) as well as in Asia (98.6% vs. 95.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.690). The 5\u2010year DSS also did not differ according to lymph node metastasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.688) or tumor location (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.474).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SC showed similar clinical outcomes (including recurrence) and survival outcomes as EC; therefore, EC is not needed for the treatment of T1b GBC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.593","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T23:50:26Z","timestamp":1545177026000},"page":"533-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Optimal surgical treatment in patients with T1b gallbladder cancer: An international multicenter study"],"prefix":"10.1002","volume":"25","author":[{"given":"Hyeong Seok","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South Korea"},{"name":"Department of Surgery Daejeon St. Mary's Hospital, College of Medicine The Catholic University of Korea Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbeom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngmin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South 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Jun","family":"Kwon","sequence":"additional","affiliation":[{"name":"School of Medicine Kyungpook National University Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Vinuela","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Faculty of Medicine Catholic University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"J\u00e1rufe","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Faculty of Medicine Catholic University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Roa","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Catholic University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Woong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Seok","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Soo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary 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