{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:16:03Z","timestamp":1785046563581,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to examine the impact of pretreatments on outcomes after living donor liver transplantation (<jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>) for hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From February 1999 to March 2015, 223 patients underwent <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>. Until December 2006, there was no restriction in patient selection criteria regarding the number and size of tumors, following which we implemented the Kyoto criteria (tumor number \u226410, maximal diameter \u22645\u00a0cm, and des\u2010gamma\u2010carboxy prothrombin \u2264400\u00a0mAU\/ml) since January 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 223 patients, 156 had a history of pretreatments. Among 101 patients meeting the Milan criteria at the initial diagnosis, 38 progressed to beyond the criteria at liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>). Twenty\u2010two out of 38 met the Kyoto criteria, and their survival and recurrence rates were significantly better than those of patients exceeding the Kyoto criteria (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004 and 0.035, respectively). Regarding the number of pretreatments (0 vs. 1\u20134 vs. \u22655), recurrence rate was significantly higher in the \u22655 pretreatments group than the 0 group. However, for patients meeting the Kyoto criteria, there were no significant differences in recurrence rates between these three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Better outcomes will be achieved by performing <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>s meeting the Kyoto criteria even after repeated pretreatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.602","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T12:28:04Z","timestamp":1545136084000},"page":"73-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of pretreatments on outcomes after living donor liver transplantation for hepatocellular carcinoma"],"prefix":"10.1002","volume":"26","author":[{"given":"Kohei","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery and Transplantation Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimi","family":"Kaido","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery and Transplantation Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Okajima","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery and Transplantation Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery and Transplantation Kyoto University Kyoto 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutsugu","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Breast Surgery Ehime University Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Uemoto","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery and Transplantation Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603143341104"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20642"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106908"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02783.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.04.056"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20526"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22412"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i43.7515"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-013-2229-y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27752"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000236600.24667.a4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200001270-00011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000072372.42396.47"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000197554.16093.d1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24563"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70284-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007122"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14964-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.12.041"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01321.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9443-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.09.021"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01863.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1301"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0618-y"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2117-x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11839"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20511"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.20.1270"}],"container-title":["Journal 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