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Despite its clinical utility, <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> can be complicated by severe adverse events such as bleeding, perforation, and peritonitis. The aim of this paper is to provide practice guidelines for safe performance of <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> as well as safe introduction of the procedure to non\u2010expert centers. The guidelines comprised patient\u2013intervention\u2013comparison\u2013outcome\u2010formatted clinical questions (<jats:styled-content style=\"fixed-case\">CQs<\/jats:styled-content>) and questions (Qs), which are background statements to facilitate understanding of the <jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>s. A literature search was performed using the PubMed and Cochrane Library databases. Statement, evidence level, and strength of recommendation were created according to the <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> system. Four committees were organized: guideline creation, expert panelist, evaluation, and external evaluation committees. We developed 13 <jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>s (methods, device selection, supportive treatment, management of adverse events, education and ethics) and six Qs (definition, indication, outcomes and adverse events) with statements, evidence levels, and strengths of recommendation. The guidelines explain the technical aspects, management of adverse events, and ethics of <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and its introduction to non\u2010expert institutions.<\/jats:p>","DOI":"10.1002\/jhbp.631","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T10:41:06Z","timestamp":1556275266000},"page":"249-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":159,"title":["Clinical practice guidelines for safe performance of endoscopic ultrasound\/ultrasonography\u2010guided biliary drainage: 2018"],"prefix":"10.1002","volume":"26","author":[{"given":"Hiroyuki","family":"Isayama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine Juntendo University Tokyo Japan"},{"name":"Department of Gastroenterology Graduate School of 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