{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:50:36Z","timestamp":1761897036367},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T00:00:00Z","timestamp":1564272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Survival benefit of liver resection for noncolorectal liver metastases (<jats:styled-content style=\"fixed-case\">NCRLM<\/jats:styled-content>) remains to be defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, retrospective cohort analysis included consecutive patients with <jats:styled-content style=\"fixed-case\">NCRLM<\/jats:styled-content> whose primary tumor and all metastases were treated with curative intent between 2000 and 2013. The primary endpoint was 5\u2010year overall survival. Clinicopathological factors that affected prognoses were identified using multivariate Cox regression analyses and were included in a predictive model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data for 205 patients were analyzed. The three most common primary tumor sites were stomach (39%), pancreas (13%), and urinary tract (10%), with adenocarcinomas the main pathology (52%). R0 resection was achieved in 85%, and the overall survival at 5\u00a0years was 41%. In the multivariate analysis, synchronous liver metastases, R1\/2 resection, and adenocarcinomas and other carcinomas (with gastrointestinal stromal tumors, neuroendocrine tumors G1\/G2, and sarcomas set as the reference group) were independent negative indicators of overall survival. A predictive model effectively stratified the <jats:styled-content style=\"fixed-case\">NCRLM<\/jats:styled-content> patients into low\u2010, intermediate\u2010, and high\u2010risk groups with overall 5\u2010year survival rates of 63%, 38%, and 21%, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients who underwent curative resection for metachronous disease and favorable tumor pathology are expected to have better survival in the <jats:styled-content style=\"fixed-case\">NCRLM<\/jats:styled-content> cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.654","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T17:28:58Z","timestamp":1562261338000},"page":"441-448","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era: a Japanese multicenter analysis"],"prefix":"10.1002","volume":"26","author":[{"given":"Taiga","family":"Wakabayashi","sequence":"first","affiliation":[{"name":"Department of Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taizo","family":"Hibi","sequence":"additional","affiliation":[{"name":"Department of Surgery Keio University School of Medicine Tokyo Japan"},{"name":"Department of Pediatric Surgery and Transplantation Kumamoto University Graduate School of Medical Sciences Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godai","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokyo Women\u2019s Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Iwao","sequence":"additional","affiliation":[{"name":"Department of 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