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In this review article, we discuss the molecular aspects of <jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content> including the role of erbB receptor tyrosine kinases (<jats:styled-content style=\"fixed-case\">RTKs<\/jats:styled-content>), downstream signaling pathways of these erbB <jats:styled-content style=\"fixed-case\">RTKs<\/jats:styled-content>, inflammatory mediators during gallbladder carcinogenesis and bile acids based on our study using a mouse model for human <jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">BK5<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">erbB2<\/jats:styled-content> mice) as well as additional information in the 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