{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:20:33Z","timestamp":1783437633286,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous findings on hepatic bile acid compositions in nonalcoholic fatty liver disease (NAFLD) have been inconsistent and complicated. The aim of this study was to investigate the effects of steatosis on hepatic bile acid composition in a hypertensive NAFLD model without obesity and diabetes mellitus and compare hepatic bile acid composition between hypertensive rats with and without steatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two groups of hypertensive rats were studied: spontaneously hypertensive rats (SHR) fed with a normal diet (SHR\u2010N) or a choline\u2010deficient diet (SHR\u2010CD). Two groups of normotensive rats were studied: Wistar Kyoto rats (WKY) fed a normal diet (WKY\u2010N) or a choline\u2010deficient diet (WKY\u2010CD). Hepatic bile acid analysis was performed using liquid chromatography\u2013electrospray ionization\u2013tandem mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding bile acid composition, the hyodeoxycholic acid (HDCA) species in the SHR\u2010CD group showed the largest change in bile acid composition, significantly decreasing to 21.9% of that found in the SHR\u2010N group. In the WKY\u2010CD group, no reduction of HDCA species was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated that the decrease in HDCA species was the main alteration in a hypertensive NAFLD model. It was suggested that the decrease in HDCA species in the SHR\u2010CD group was caused by dysbiosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.678","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T08:55:13Z","timestamp":1569660913000},"page":"557-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model"],"prefix":"10.1002","volume":"26","author":[{"given":"Masanobu","family":"Kodama","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine Hiroshima University Hospital 1\u20102\u20103 Kasumi, Minami\u2010ku Hiroshima 734\u20108551 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department 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1\u20102\u20103 Kasumi, Minami\u2010ku Hiroshima 734\u20108551 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