{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T22:55:12Z","timestamp":1756076112460},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The resection of liver tumors that involve the hepatic veins adjacent to the vena cava or hepatic hilum is technically challenging. We present our surgical techniques and the long\u2010term outcome of five patients with conventionally unresectable tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five patients with conventionally unresectable tumors were successfully treated by \u201cex\u2010situ liver resection\u201d and \u201cin\u2010situ and ante\u2010situm hypothermic liver perfusion\u201d under total vascular exclusion and venovenous bypass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>These approaches allowed complete tumor removal with vascular reconstruction under a bloodless surgical field, while minimizing hepatic ischemic injury and preserving liver function. No perioperative mortalities occurred, and postoperative complications were minimal. The postoperative survival periods were limited due to the advanced malignancies in our patients, but the survival benefit was encouraging. The median postoperative survival time was 29.1\u00a0months, with the longest survival period being nearly 10\u00a0years. These approaches improved the quality of life and provided an opportunity for additional treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypothermic perfusion hepatectomy is a realistic option for achieving surgical cure or significantly improved survival and quality of life in patients with tumors deemed unresectable using conventional normothermic hepatectomy. These approaches can overcome the limitations of the liver's restricted normothermic ischemia tolerance or inaccessible tumor locations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.681","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T09:05:14Z","timestamp":1569661514000},"page":"254-264","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hypothermic perfusion hepatectomy for unresectable liver cancer: A single\u2010center experience"],"prefix":"10.1002","volume":"27","author":[{"given":"Young\u2010In","family":"Yoon","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deok\u2010Bog","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheon\u2010Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery Eunpyeong St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul 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