{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:38:48Z","timestamp":1771918728391,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K11928"],"award-info":[{"award-number":["24K11928"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Overexpression of human epidermal growth factor receptor 2 (HER2) is a recognized prognostic marker and therapeutic target in oncology. However, its clinical significance in intraductal papillary neoplasm of the bile duct (IPNB) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study reviewed patients who underwent resection for IPNB between 1998 and 2011. HER2 overexpression was evaluated by immunohistochemistry and semi\u2010quantitatively categorized into four grades (score 0, 1+, 2+, 3+); the former two and the latter two grades defined HER2\u2010negative and HER2\u2010positive groups, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 184 IPNB cases were analyzed, of which 12 patients (6.5%) were diagnosed with HER2\u2010positive disease. There were no significant differences between the groups in clinicopathologic characteristics such as tumor location, histologic type, or invasion depth, with the exception of superficial extension, which was significantly more frequent in the HER2\u2010positive group. The HER2\u2010positive group demonstrated significantly worse overall survival than the HER2\u2010negative group (25% vs. 49% at 5\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). In multivariable analysis, HER2 positivity, age\u2009\u2265\u200970, percutaneous transhepatic biliary drainage, nodal metastasis, and positive margin status were identified as independent prognostic factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HER2 overexpression is an independent biologic marker for unfavorable survival, though infrequent in IPNB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70000","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T09:07:44Z","timestamp":1756112864000},"page":"838-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Impact of\n                    <scp>HER2<\/scp>\n                    Overexpression in Intraductal Papillary Neoplasm of the Bile Duct"],"prefix":"10.1002","volume":"32","author":[{"given":"Shunsuke","family":"Onoe","sequence":"first","affiliation":[{"name":"Department of Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8802-1188","authenticated-orcid":false,"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kawakatsu","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagoya University Graduate School of Medicine  Nagoya 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