{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:47:49Z","timestamp":1791575269825,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Purpose<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) may impact surgical outcomes of acute cholecystitis due to immune dysfunction and systemic inflammation. This study evaluated short\u2010term outcomes of cholecystectomy in SLE patients using US Nationwide Readmissions Database data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults (\u2265\u200918\u2009years) admitted with acute cholecystitis who underwent cholecystectomy between 2016 and 2020 were included. Patients with cholecystostomy or missing data were excluded. After 1:4 propensity score matching, multivariable logistic regression assessed associations between SLE and postoperative outcomes, with results reported as adjusted odds ratios (aORs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 4400 patients were analyzed (880 with SLE; 3520 without). SLE was associated with higher odds of complications (aOR\u2009=\u20091.64, 95% CI: 1.30\u20132.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), particularly sepsis (aOR\u2009=\u20092.41, 95% CI: 1.55\u20133.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and acute kidney injury (aOR\u2009=\u20091.64, 95% CI: 1.23\u20132.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). SLE patients also had increased 30\u2010day (aOR\u2009=\u20091.59, 95% CI: 1.24\u20132.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 90\u2010day (aOR\u2009=\u20091.61, 95% CI: 1.31\u20131.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) readmission rates, longer hospital stays (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20091.04\u2009days), and higher costs (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u200913.01, 95% CI: 7.23\u201318.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SLE is independently linked to worse short\u2010term outcomes following cholecystectomy for acute cholecystitis. Tailored perioperative strategies are warranted for this high\u2010risk group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70004","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:09:39Z","timestamp":1757909379000},"page":"829-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Systemic Lupus Erythematosus (\n                    <scp>SLE<\/scp>\n                    ) on Short\u2010Term Outcomes of Cholecystectomy for Acute Cholecystitis: An Analysis of the\n                    <scp>US<\/scp>\n                    National Readmission Database, 2016\u20132020"],"prefix":"10.1002","volume":"32","author":[{"given":"Shao Ciao","family":"Luo","sequence":"first","affiliation":[{"name":"Division of General Surgery, Department of Surgery Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Golden\u2010Ager Industry Management Cho Yang University of Technology  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei\u2010Heng","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te\u2010Cheng","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Medical Imaging Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u2010Yuan","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsuan","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Oncology Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Oncology Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5652-0761","authenticated-orcid":false,"given":"Ming\u2010Chih","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Division of Thoracic Surgery, Department of Surgery Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University  Taichung 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