{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:30:00Z","timestamp":1790771400934,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Researches revealed a close correlation between serum lipid and tumor prognosis. The current study aimed to explore the predictive value of preoperative serum lipid levels for the postoperative prognosis of distal cholangiocarcinoma (dCCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study retrospectively included 203 dCCA patients who underwent radical surgery in our department. The Kaplan\u2013Meier method and Cox regression model were used for univariate and multivariate analysis. Six machine\u2010learning models were used to build a prediction model for postoperative prognosis. Subgroup and correlation analyses were conducted to reveal influencing factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Preoperative high\u2010density lipoprotein cholesterol (HDL\u2010c) had the best area under the ROC curve with a cutoff value of 0.415\u2009mmol\/L. Overall survival and disease\u2010free survival were significantly lower in the low HDL\u2010c group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Univariate and multivariate analyses identified HDL\u2010c\u2009\u2264\u20090.415\u2009mmol\/L as an independent risk factor for postoperative tumor recurrence and overall survival. The survival prediction model incorporating HDL\u2010c constructed by the random forest model exhibited optimal prediction value. Subgroup analysis confirmed HDL\u2010c\u2009\u2264\u20090.415\u2009mmol\/L as an independent risk factor for postoperative tumor recurrence and overall survival in patients with tumor infiltration depth\u2009\u2265\u200912\u2009mm, lymph node metastasis and elevated preoperative CA19\u20109.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HDL\u2010c\u2009\u2264\u20090.415\u2009mmol\/L is an independent risk factor for postoperative prognosis in dCCA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70022","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:03:47Z","timestamp":1761894227000},"page":"113-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative Serum High\u2010Density Lipoprotein Cholesterol Serves as a Prognostic Marker for Postoperative Prognosis of Distal Cholangiocarcinoma"],"prefix":"10.1002","volume":"33","author":[{"given":"Han\u2010xuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang Hospital Affiliated to Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010can","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang Hospital Affiliated to Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010cheng","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang Hospital Affiliated to Capital Medical University  Beijing 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