{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:46:47Z","timestamp":1790095607050,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of neoadjuvant gemcitabine, cisplatin, and S\u20101 (GCS) chemotherapy for resectable biliary tract cancer (BTC) and FDG\u2010PET\u2010positive lymph nodes in a multicenter phase II study (KHBO1201).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with resectable BTC (intrahepatic\/extrahepatic bile duct, gallbladder, or ampullary cancers) and FDG\u2010PET\u2010positive lymph nodes received GCS chemotherapy: gemcitabine\/cisplatin on Day 1 and oral S\u20101 for 7\u2009days, repeated every 2\u2009weeks for 3\u20136\u2009cycles. Surgery was planned 4\u20138\u2009weeks later if the tumor was deemed resectable. The primary endpoint was the curative resection rate. Secondary endpoints were the completion rate, radiological response, radiological\/pathological complete response (CR) of FDG\u2010PET\u2010positive lymph nodes, and 1\u2010year survival (UMIN000009831).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010five patients were enrolled. Twenty\u2010three (92%) completed GCS without treatment\u2010related deaths; grade 3 biliary infection occurred in 8.0%. Curative resection was achieved in 60% with a morbidity rate of 40%. The radiological response rate was 13%, and the radiological and pathological CR rates of FDG\u2010PET\u2010positive lymph nodes were 24% and 28%, respectively. The 1\u2010year survival rate was 75%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neoadjuvant GCS chemotherapy is safe, feasible, and potentially effective for resectable BTC with FDG\u2010PET\u2010positive lymph nodes. A randomized phase III trial (JCOG1920) is underway to compare neoadjuvant GCS chemotherapy with upfront surgery (jRCTs031200388).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70030","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T04:36:11Z","timestamp":1763354171000},"page":"104-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neoadjuvant Chemotherapy With Gemcitabine\/Cisplatin\/S\u20101 for Resectable Biliary Tract Cancer With\n                    <scp>FDG<\/scp>\n                    \u2010\n                    <scp>PET<\/scp>\n                    \u2010Positive Lymph Node Metastasis (\n                    <scp>KHBO1201<\/scp>\n                    ): A Multicenter Phase\n                    <scp>II<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"33","author":[{"given":"Satoshi","family":"Ogiso","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-1918","authenticated-orcid":false,"given":"Etsuro","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Surgery Kochi Medical School  Nankoku\u2010City Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Kyoto University Hospital  Kyoto Japan"},{"name":"Cancer Treatment Center Kansai Medical University Hospital  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