{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:44:15Z","timestamp":1773776655219,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Purpose<\/jats:title>\n                    <jats:p>Accurate assessment of tumor invasion depth is essential for determining the surgical strategy for gallbladder cancer; however, preoperative assessment remains challenging. This study assessed the utility of intraoperative narrow\u2010band imaging (NBI) of the gallbladder serosal surface for estimating tumor invasion depth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010nine patients with suspected gallbladder cancer underwent intraoperative observation of the gallbladder serosa using NBI. The NBI findings were classified based on vascular irregularities and correlated with postoperative histopathological data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 39 patients, 26 (66.7%) were diagnosed with gallbladder cancer. All patients with positive NBI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) were pathologically confirmed to have gallbladder cancer. Positive NBI was significantly associated with \u2265 T2 invasion and increased microvasculature in the subserosal layer (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as well as with lymphatic invasion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Diagnostic sensitivities for \u2265 T2 invasion were 79.5% for intraoperative NBI, 69.4% for plane CT, and 63.0% for EUS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoperative NBI may be useful for evaluating tumor depth and lymphatic involvement in patients suspected to have gallbladder cancer, which can support intraoperative surgical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70038","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:51:10Z","timestamp":1764064270000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intraoperative Narrow\u2010Band Imaging Predicts Invasion Depth in Gallbladder Cancer"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-259X","authenticated-orcid":false,"given":"Yuiko","family":"Nagasawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teijiro","family":"Hirashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Iwashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Miyoshino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroomi","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Inomata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu City Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.870"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b5d5fc"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3781-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.603"},{"key":"e_1_2_9_6_1","volume-title":"TNM Classification of Malignant Tumours","author":"Brierley J. 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