{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:19:35Z","timestamp":1789391975149,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive post\u2010GWAS analysis using large\u2010scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated multi\u2010omics data via transcriptome\u2010wide and proteome\u2010wide association studies, and resolved cell\u2010type\u2010specific effects using single\u2010cell analysis. Extensive locus colocalization analyses were performed to validate our findings by estimating the probability of shared causal variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This computational discovery phase prioritized 29 high\u2010confidence pleiotropic genes, including established loci (\n                      <jats:italic>SPINK1, CRP<\/jats:italic>\n                      ) and novel candidates (\n                      <jats:italic>ERBB2, ALDH2, FLOT1<\/jats:italic>\n                      ). To functionally validate and contextualize these findings, we performed bulk transcriptomic analysis on peripheral blood from AP patients and employed gsMap, a spatial GWAS mapping algorithm, to integrate our genetic data with transcriptomics from a murine AP model, comparing pathological versus normal tissue. These analyses confirmed that the identified genes are dynamically regulated in a severity\u2010dependent manner in patients and are activated within specific pathological niches in pancreatic tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, this study provides a genetic map linking AP and its infectious comorbidities, offering insights into potential prevention strategies and highlighting novel therapeutic targets for further investigation and validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70041","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:09:47Z","timestamp":1764313787000},"page":"194-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-7683","authenticated-orcid":false,"given":"Bo","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine Affiliated Hospital of Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsheng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Jinshan Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daifeng","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Computing, Engineering &amp; Digital Technologies Teesside University  Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4059-547X","authenticated-orcid":false,"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-0953","authenticated-orcid":false,"given":"Shanshan","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Sciences, Faculty of Health and Medicine Lancaster University  Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-9043","authenticated-orcid":false,"given":"Xinglin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine First Affiliated Hospital of Army Medical University  Chongqing 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