{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:44:12Z","timestamp":1773776652860,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Recently, surgical resection has been attempted for postoperative recurrence of pancreatic ductal adenocarcinoma (\n PDAC<\/jats:styled-content>\n ). This multicenter study aimed to investigate whether resection of any recurrent lesion contributes to the survival of patients with\n PDAC.<\/jats:styled-content>\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective study of the Hepato\u2010Pancreato\u2010Biliary Scientific Network for Clinical Oncology Research Working Cohort involved patients with resectable\/borderline resectable\n PDAC<\/jats:styled-content>\n who underwent surgery between 2013 and 2019 and who subsequently developed recurrence after resection of the primary\n PDAC<\/jats:styled-content>\n . A time\u2010dependent Cox regression model adjusted for various patient background and clinicopathological factors was used.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study cohort comprised 1527 patients; 96 underwent resection for recurrence, including hepatectomy in 12 patients, pneumonectomy in 40, and pancreatectomy in 42. Overall survival after the initial treatment of primary\n PDAC<\/jats:styled-content>\n was significantly better in patients who underwent resection compared with those who did not (75.0 vs. 25.8\u2009months). The time\u2010dependent Cox regression model indicated that pneumonectomy for lung metastasis (\n HR<\/jats:styled-content>\n \u2009=\u20090.12) and pancreatectomy for recurrence in the pancreatic remnant (\n HR<\/jats:styled-content>\n \u2009=\u20090.20) significantly affected overall survival, whereas hepatectomy for liver metastasis was not (\n HR<\/jats:styled-content>\n \u2009=\u20090.46).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Resection for postoperative recurrence of\n PDAC<\/jats:styled-content>\n may offer survival benefits for selected patients, especially for lung metastasis and residual pancreatic recurrence.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n https:\/\/ClinicalTrials.gov<\/jats:ext-link>\n identifier: UMIN000049664\n <\/jats:p>\n 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