{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:12:53Z","timestamp":1790709173657,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012412","name":"Kansai Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate adverse events (AEs) for endoscopic ultrasound\u2010guided biliary drainage (EUS\u2010BD) and identify risk factors for early AEs and recurrent biliary obstruction (RBO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective study was conducted using a common database of 21 Japanese referral centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 616 patients who underwent EUS\u2010BD, including endoscopic ultrasound\u2010guided choledochoduodenostomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009107), hepaticogastrostomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009487), and hepaticojejunostomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), for malignant biliary obstruction were analyzed. Early AEs occurred in 13.6% of patients. Independent risk factors for all AEs included procedure time\u2009\u2265\u200932\u2009min (odds ratio [OR] 1.82) and antiplatelet\/anticoagulant use (OR 2.15). A risk factor for peritonitis included electrocautery use (OR 3.87), while bleeding risk was increased with antiplatelet\/anticoagulant use (OR 7.19) and performance status\u2009&gt;\u20092 (OR 5.26). The use of plastic stents was associated with a higher risk of a shorter time to RBO. AE and RBO rates did not significantly differ among the three EUS\u2010BD approaches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients on antiplatelet and\/or anticoagulation therapy should be aware of the increased risk of AEs of EUS\u2010BD. In addition, it is important to minimize procedure time, avoid the use of electrocautery, and use a metal stent to prevent early AEs and RBO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70055","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T04:37:01Z","timestamp":1766810221000},"page":"228-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adverse Events of\n                    <scp>EUS<\/scp>\n                    \u2010Guided Biliary Drainage for Malignant Biliary Obstruction: A Large Multicenter Study"],"prefix":"10.1002","volume":"33","author":[{"given":"Masahiro","family":"Itonaga","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-6568","authenticated-orcid":false,"given":"Takeshi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Diseases, Department of Gastroenterology Hyogo Medical University  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-8210","authenticated-orcid":false,"given":"Shuhei","family":"Shintani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Shiga University of Medical Science  Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Faculty of Medicine Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3039-2303","authenticated-orcid":false,"given":"Koichiro","family":"Mandai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyoto Second Red Cross Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okanami General Hospital  Iga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tane General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Ikeura","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Division of Gastroenterology and Hepatology Kansai Medical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-8804","authenticated-orcid":false,"given":"Nao","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Minami Wakayama Medical Center  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ikezawa","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Sugimori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5794-1512","authenticated-orcid":false,"given":"Koh","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Sagami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Kokubu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Metabology Ehime University Graduate School of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taira","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobu","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Hatamaru","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Minaga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1563-7181","authenticated-orcid":false,"given":"Ke","family":"Wan","sequence":"additional","affiliation":[{"name":"Clinical Research Center Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Clinical Research Center Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6885-9223","authenticated-orcid":false,"given":"Masayuki","family":"Kitano","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.07.047"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2023.294"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14428"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.631"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.10.033"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.06.055"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13184"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.10.027"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-10731-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X16671671"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14825"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.01.055"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01798-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.054"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.08.001"},{"key":"e_1_2_11_17_1","article-title":"Feasibility and Safety of EUS\u2010Guided Biliary Drainage in Inexperienced Centers: A Multicenter Study in Southwest Japan","author":"Koga T.","year":"2024","journal-title":"Gastrointestinal Endoscopy"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13300"},{"key":"e_1_2_11_19_1","article-title":"Usefulness of a Dedicated Laser\u2010Cut Metal Stent With an Anchoring Hook and Thin Delivery System for Endoscopic Ultrasound\u2010Guided Hepaticogastrostomy in Malignant Biliary Obstruction: A Prospective Multicenter Trial (With Video)","author":"Itonaga M.","year":"2024","journal-title":"Gastrointestinal Endoscopy"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221092612"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13620"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31828c6822"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/eus.eus_2_18"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.04.038"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/EUS-D-21-00251"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2022.211"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14956"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14956"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2024.07.011"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.70055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhbp.70055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.70055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:48:13Z","timestamp":1773766093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.70055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/jhbp.70055"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.70055","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"2025-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}