{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:07:14Z","timestamp":1779790034450,"version":"3.53.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Contrast\u2010enhanced endoscopic ultrasonography (CE\u2010EUS) provides clearer visualization of wall layer structures in gallbladder nodules than B\u2010mode EUS. This study aimed to compare the diagnostic performance of B\u2010mode EUS and CE\u2010EUS in differentiating benign from malignant gallbladder lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent both B\u2010mode EUS and CE\u2010EUS for gallbladder nodules with available pathological diagnoses were retrospectively analyzed. The diagnostic findings of each modality were evaluated by univariate and multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010six patients were included (31 malignant, 55 benign). On B\u2010mode EUS, a pedunculated shape and presence of a Rokitansky\u2013Aschoff sinus were associated with benignity, whereas diameter \u2265\u200920\u2009mm and an unclear or disrupted wall layer structure were associated with malignancy. On CE\u2010EUS, unclear or disrupted wall layer structure was strongly associated with malignancy, whereas enhancement patterns showed only univariate significance. Multivariate analysis identified unclear or disrupted wall layer structure on CE\u2010EUS and diameter \u2265\u200920\u2009mm as independent predictors of malignancy. Diagnostic accuracy was significantly higher with CE\u2010EUS evaluation of wall layer structure (93%) than with B\u2010mode EUS evaluation of maximum diameter (78%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CE\u2010EUS, particularly assessment of wall layer structure, improves differentiation between benign and malignant gallbladder nodules and complements B\u2010mode EUS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70069","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:08:11Z","timestamp":1769170091000},"page":"380-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Contrast\u2010Enhanced Endoscopic Ultrasound in the Diagnosis of Gallbladder Tumor: A Retrospective Multicenter Cohort Study"],"prefix":"10.1002","volume":"33","author":[{"given":"Kensaku","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Gifu Prefectural General Medical Center  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Maruta","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Gifu University Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Uemura","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Gifu University Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gifu Municipal Hospital  Gifu 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