{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:01:10Z","timestamp":1784887270249,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Management of pancreatic neuroendocrine tumors (pNETs) &lt;\u200920\u2009mm remains controversial. Endoscopic ultrasound\u2010guided tissue acquisition is crucial for diagnosis and grading, but data on small pNETs and Ki\u201067 sample adequacy are limited. This systematic review and meta\u2010analysis evaluated sample adequacy, diagnostic yield, and histologic concordance with surgical specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of MEDLINE, EMBASE, and SCOPUS was conducted. Studies reporting diagnostic yield or concordance between EUS\u2010guided fine\u2010needle aspiration (FNA) or biopsy (FNB) and surgical histology in pNETs &lt;\u200920\u2009mm were included. The primary outcomes were diagnostic yield, concordance with surgical histology, and adequacy of samples for Ki\u201067\u2010based tumor grading. Pooled estimates were calculated using random\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>27 studies were included: 17 reported sample adequacy, 9 diagnostic yield, 13 grade concordance, and 5 both yield and grading. Pooled diagnostic yield was 84.4% (95% CI: 0.80\u20130.87) and pooled concordance rate was 84.2% (95% CI: 0.803\u20130.882). For sample adequacy to establish tumor grade, the pooled rate was 71.6%. Notably, EUS\u2010FNB demonstrated significantly higher adequacy (79.8%) compared to FNA (52.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EUS\u2010guided tissue acquisition offers high diagnostic accuracy and reliable tumor grading in pNETs &lt;\u200920\u2009mm. FNB outperforms FNA in obtaining adequate tissue for grading, underscoring its importance in clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70075","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:35:39Z","timestamp":1770957339000},"page":"526-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Utility of\n                    <scp>EUS<\/scp>\n                    \u2010\n                    <scp>FNA<\/scp>\n                    \/\n                    <scp>FNB<\/scp>\n                    for Diagnosis and Grade Assessment in Pancreatic Neuroendocrine Tumors &lt;\u200920\u2009mm: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"33","author":[{"given":"Francisco","family":"Valverde\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital 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