{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:24Z","timestamp":1786978164888,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gallstones are a common digestive disorder linked to a bile composition imbalance. Uric acid (UA) and high\u2010density lipoprotein cholesterol (HDL\u2010C) are key metabolic markers associated with gallstone risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between the uric acid to HDL\u2010C ratio (UHR) and gallstone risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using 2017\u20132020 NHANES data, we included participants with complete UHR and gallstone information. Analyses included weighted multivariate logistic regression, restricted cubic splines (RCS) for nonlinearity, subgroup\/interaction tests, and sensitivity analysis using multiple imputation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 6354 participants, UHR was positively associated with gallstones. The fully adjusted model revealed that for every 1\u2010unit increase in UHR, the incidence of gallstones increased by 4% (OR\u2009=\u20091.04, 95% CI: 1.00\u20131.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045). RCS indicated a nonlinear relationship (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>nonlinear<\/jats:sub>\n                      &lt;\u20090.001) with an inflection at 14.6: risk increased significantly below 14.6 but weakened above it. Subgroup analysis revealed a remarkable interaction within the asthma subgroup (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>forinteraction<\/jats:sub>\n                      \u2009=\u20090.017). Sensitivity analysis corroborated the robustness of these findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>UHR, a novel inflammatory and metabolic marker, is closely related to gallstone risk. Its predictive value is particularly high in the lower range (&lt;\u200914.6), offering a new reference for screening high\u2010risk populations for gallstones.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70076","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:13:34Z","timestamp":1770444814000},"page":"371-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Uric Acid to High\u2010Density Lipoprotein Cholesterol Ratio and Gallstones: A\n                    <scp>NHANES<\/scp>\n                    Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"33","author":[{"given":"Lichun","family":"Yu","sequence":"first","affiliation":[{"name":"Abdominal Tumor Surgery Fuyang Cancer Hospital  Fu Yang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Abdominal Tumor Surgery Fuyang Cancer Hospital  Fu Yang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjin","family":"Wang","sequence":"additional","affiliation":[{"name":"Abdominal Tumor Surgery Fuyang Cancer Hospital  Fu Yang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengtao","family":"Liu","sequence":"additional","affiliation":[{"name":"Abdominal Tumor Surgery Fuyang Cancer Hospital  Fu Yang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Xu","sequence":"additional","affiliation":[{"name":"Abdominal Tumor Surgery Fuyang Cancer Hospital  Fu Yang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihua","family":"Wu","sequence":"additional","affiliation":[{"name":"Abdominal Tumor Surgery Fuyang Cancer Hospital  Fu Yang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.24"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.01.051"},{"key":"e_1_2_12_4_1","volume-title":"Statpearls","author":"Jones M. 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