{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:15:46Z","timestamp":1792167346755,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Purpose<\/jats:title>\n                    <jats:p>Prognostic significance of preoperative patient\u2010related factors, including oral health status, in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We evaluated the association between preoperative factors\u2014particularly oral health parameters\u2014and long\u2010term survival after curative PDAC resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent radical pancreatectomy for PDAC (2014\u20132022) were retrospectively analyzed. Preoperative factors, including oral health status (natural tooth count and posterior teeth occlusion), clinical characteristics, and immuno\u2010nutritional markers, were assessed for their association with overall survival (OS). Multivariate models adjusted for established pathological and treatment\u2010related prognostic variables were further analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 343 eligible patients, 339 underwent preoperative dental examinations; 135 had \u2264\u200920 teeth and 204 had \u2265\u200921 teeth. Patients with \u2264\u200920 teeth had significantly poorer OS (median survival: 39.1 vs. 60.7\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Posterior teeth occlusion was not associated with OS. In multivariate analysis of preoperative factors, natural tooth count was independently associated with OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). This association remained significant after adjustment for established prognostic variables (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.016), whereas other immuno\u2010nutritional markers did not emerge as independent prognostic factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Post\u2010PDAC resection, natural tooth count, but not posterior teeth occlusion, is independently associated with OS. Tooth count may reflect long\u2010term host vulnerability and serve as a prognostic marker in PDAC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70113","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:58:47Z","timestamp":1777003127000},"page":"720-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Independent Prognostic Value of Natural Tooth Count Versus Posterior Teeth Occlusion in Resected Pancreatic Cancer"],"prefix":"10.1002","volume":"33","author":[{"given":"Kaoru","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-6268","authenticated-orcid":false,"given":"Kenichiro","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-1123","authenticated-orcid":false,"given":"Kenjiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuaki","family":"Sumiyoshi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Shintakuya","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Hiroshima Memorial Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima 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(Plymouth Meeting PA: National Comprehensive Cancer Network 2025) accessed September 10 2025 https:\/\/www.nccn.org\/guidelines\/nccn\u2010guidelines."},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001105"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.08.041"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010016\u20103491\u20104"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516657992"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.07.002"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2015.10.034"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010024\u201013244\u2010z"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519889021"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010312580"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.70113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhbp.70113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.70113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:30:17Z","timestamp":1790076617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.70113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jhbp.70113"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.70113","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"2026-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}