{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:52:55Z","timestamp":1790290375423,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Relationship between timing of initiating adjuvant chemotherapy (AC) and clinical outcomes after surgery for pancreatic cancer remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this ancillary analysis of the JASPAC 01 trial, 187 patients were classified according to the interval between surgery and chemotherapy initiation to Early (&lt;\u20096\u2009weeks,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945), Standard (6\u20138\u2009weeks,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970), and Delayed (&gt;\u20098\u2009weeks,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972). Overall survival (OS) and relapse\u2010free survival (RFS) were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were comparable among three groups. The Standard group showed significantly longer OS than the Early group (median, 66 vs. 37\u2009months; HR 0.61, 95% CI 0.38\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041), and relatively longer OS compared with the Delayed group (median, 45\u2009months; HR 0.68, 95% CI 0.44\u20131.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.077). RFS was longer in the Standard group (median, 46\u2009months) compared with the Early group (20\u2009months; HR 0.61, 95% CI 0.38\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040) and the Delayed group (20\u2009months; HR 0.59, 95% CI 0.39\u20130.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). Multivariate analysis identified operative procedure, R1 resection, lymph node metastasis, and nonstandard initiation (&lt;\u20096 or &gt;\u20098\u2009weeks) as independent adverse prognostic factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Initiation of S\u20101 AC at 6\u20138\u2009weeks after pancreatectomy was associated with favorable survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70117","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:15:10Z","timestamp":1776489310000},"page":"568-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Timing of Adjuvant S\u20101 Chemotherapy and Survival After Pancreatectomy for Pancreatic Cancer: An Ancillary Analysis of the\n                    <scp>JASPAC<\/scp>\n                    01 Trial"],"prefix":"10.1002","volume":"33","author":[{"given":"Dongha","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiyasu","family":"Okamura","sequence":"additional","affiliation":[{"name":"Division of Digestive Surgery, Department of Surgery Nihon University School of Medicine  Itabashi\u2010ku Tokyo Japan"},{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Nanno","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine  Kobe Hyogo 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Cancer Center Hospital East  Kashiwa\u2010shi Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirochika","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Surgery Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fukutomi","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal Oncology Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narikazu","family":"Boku","sequence":"additional","affiliation":[{"name":"Department of Oncology and General Medicine IMSUT Hospital, Institute of Medical Science, University of Tokyo  Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Uesaka","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Shizuoka Cancer Center  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