{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:26:55Z","timestamp":1787081215150,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>While normothermic machine perfusion (NMP) has benefits over static cold storage (SCS), its efficacy in high\u2010acuity recipients with high Model for End\u2010Stage Liver Disease (MELD) scores, particularly using a back\u2010to\u2010base application model, is not well established. We aimed to compare short\u2010term outcomes between NMP and SCS in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study analyzed 215 adult recipients with a laboratory MELD score\u2009\u2265\u200925 who underwent isolated liver transplantation from donation after brain death (DBD) donors between July 2022 and June 2024. Patients were divided into SCS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009137; median MELD, 35) and NMP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978; median MELD, 36) groups. Outcomes were compared using multivariable regression analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NMP was associated with higher daytime surgery rates (88.5% vs. 23.4%) and lower peak alanine aminotransferase levels (median 298 vs. 653\u2009IU\/L). However, no significant differences were found in blood loss, early allograft dysfunction, acute kidney injury, comprehensive complication index, hospital stay, or 90\u2010day graft survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In high\u2010MELD recipients of DBD grafts, a predominantly back\u2010to\u2010base NMP approach did not improve major short\u2010term clinical outcomes compared to SCS. Benefits of NMP appear to be highly context\u2010dependent across three axes\u2014graft type, application model (upfront vs. back\u2010to\u2010base), and recipient acuity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70129","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:17:14Z","timestamp":1778303834000},"page":"605-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Normothermic Machine Perfusion vs. Static Cold Storage for\n                    <scp>DBD<\/scp>\n                    Liver Transplantation in High\u2010\n                    <scp>MELD<\/scp>\n                    Recipients: A Single\u2010Center Retrospective Study"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-1544","authenticated-orcid":false,"given":"Yuzuru","family":"Sambommatsu","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-8021","authenticated-orcid":false,"given":"Daisuke","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-5065","authenticated-orcid":false,"given":"Kush","family":"Savsani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Tarashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Hallesy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-2225","authenticated-orcid":false,"given":"Isao","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4382-7871","authenticated-orcid":false,"given":"Seung Duk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery, Hume\u2010Lee Transplant Center Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0047-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.6781"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000560"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005934"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15049"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2024.6520"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006032"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006291"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000548"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.70170"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577511"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01242.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15014"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22091"},{"issue":"2","key":"e_1_2_11_16_1","first-page":"3","article-title":"KDIGO Board Members","volume":"2012","author":"KDIGO board members","year":"2011","journal-title":"Kidney International. Supplement"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318296c732"},{"key":"e_1_2_11_18_1","article-title":"Machine Perfusion in Liver Transplantation","volume":"9","author":"Tingle S. J.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00892"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.04.013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006634"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000344"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000376"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.70129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhbp.70129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:53:40Z","timestamp":1787079220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jhbp.70129"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.70129","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}