{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:28:27Z","timestamp":1786343307082,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To determine the impact of symptomatic status on perioperative outcomes and assess optimal surgical timing for asymptomatic children with prenatally diagnosed congenital biliary dilatation (CBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed prenatally diagnosed CBD cases from 2015 to 2024, classified as symptomatic or asymptomatic. Demographics, liver fibrosis grade, and perioperative outcomes were compared between groups. Then, asymptomatic patients were subdivided into early (\u2264\u200930\u2009days) and delayed (&gt;\u200930\u2009days) surgery groups for further comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 574 patients, 305 were symptomatic and 269 were asymptomatic. The symptomatic group had a longer operative time [180.0 (150.0, 223.5) vs. 160.0 (133.0, 190.0) min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001], higher incidence of liver fibrosis (34.1% vs. 24.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), longer drainage duration [4 (3.5) vs. 3 (3.4) days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001], and longer postoperative stay [7 (6.9) vs. 7 (6.8) days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001] compared with the asymptomatic group. Among asymptomatic infants, no significant differences were observed in operative time[154.0 (132.5, 197.0) vs. 160.0 (133.0, 190.0) min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.890] or short\u2010term complications (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) between the early and delayed surgery groups. However, all eight cases of stage F4 liver fibrosis occurred in the delayed surgery group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgery after symptom onset in prenatally diagnosed CBD increases fibrosis risk. Asymptomatic early surgery is safe and may reduce advanced fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70162","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T05:38:51Z","timestamp":1786340331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Timing of Prenatally Diagnosed Congenital Biliary Dilatation Surgery: A Retrospective Cohort Study"],"prefix":"10.1002","author":[{"given":"Kaikun","family":"Huang","sequence":"first","affiliation":[{"name":"Capital Institute of Pediatrics  Beijing China"},{"name":"Department of General Surgery, Capital Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Capital Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital Capital Medical University, Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anxiao","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Capital Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Capital Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Capital Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[{"name":"Capital Institute of Pediatrics  Beijing China"},{"name":"Department of General Surgery, Capital Center for Children's Health Capital Medical University  Beijing China"},{"name":"Department of Pediatric Surgery Tsinghua University Affiliated Beijing Tsinghua Changgung Hospital  Beijing China"},{"name":"Research Unit of Minimally Invasive Pediatric Surgery on Diagnosis and Treatment Chinese Academy of Medical Sciences 2021RU015  Beijing 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