{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:26:44Z","timestamp":1787232404444,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K11864"],"award-info":[{"award-number":["24K11864"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cholangiolocarcinoma (CLC) is a rare liver cancer with \u2265\u200980% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide multicenter study with centralized pathological review to investigate the features of CLC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included patients with a postoperative diagnosis of CLC at 49 participating institutions (2005\u20132018). All cases were re\u2010evaluated by centralized pathology according to the WHO classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 196 re\u2010evaluated patients, 56 tumors were classified as CLC, 69 as intrahepatic cholangiocarcinoma (iCCA) with &lt;\u200980% DC, 53 as small\u2010duct type iCCA with DC, and 16 as mixed small\u2010 and large\u2010duct type (SD\/LD\u2010iCCA with DC). CLC showed a low prevalence of viral hepatitis (23.2%), frequent arterial enhancement (83.9%), and characteristic apical EMA positivity. The median overall survival (OS) was 10.8\u2009years, with 5\u2010 and 10\u2010year OS rates of 85.0% and 73.7%, respectively, which were significantly better than those of SD\/LD\u2010iCCA with DC. Recurrence occurred in 38.2% of CLC cases with favorable outcomes following surgical resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CLC exhibits distinct pathological and prognostic features, including favorable long\u2010term survival, supporting CLC as a distinct clinicopathological entity. Further molecular research is needed to refine the classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This study was registered with the UMIN Clinical Trials Registry (UMIN000057919)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70170","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:34:51Z","timestamp":1786703691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-9653","authenticated-orcid":false,"given":"Takamichi","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"},{"name":"Department of Surgery for Abdominal Oncology and Organ Regeneration, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-8915","authenticated-orcid":false,"given":"Kenta","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-1918","authenticated-orcid":false,"given":"Etsuro","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-1417","authenticated-orcid":false,"given":"Mina","family":"Komuta","sequence":"additional","affiliation":[{"name":"Department of Pathology International University of Health and Welfare School of Medicine, IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7279-9702","authenticated-orcid":false,"given":"Yoshihiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Kyorin University Hospital  Mitaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010Ichi","family":"Ariizumi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Gastroenterology Tokyo Women's Medical University  Tokyo 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Hepato\u2010Biliary\u2010Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Yasuchika","sequence":"additional","affiliation":[{"name":"Department of Surgery Japanese Red Cross Wakayama Medical Center  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-7572","authenticated-orcid":false,"given":"Daisuke","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine Institute of Science Tokyo  Tokyo 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