{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:18:24Z","timestamp":1788513504030,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02981"],"award-info":[{"award-number":["23H02981"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26K19644"],"award-info":[{"award-number":["26K19644"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["25fk0210165"],"award-info":[{"award-number":["25fk0210165"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hepatocellular carcinoma (HCC) remains a major cause of cancer\u2010related mortality worldwide, and postoperative recurrence continues to limit long\u2010term survival. Liver\u2010resident natural killer (NK) cells are key effectors of antitumor immunity in the hepatic microenvironment. Interleukin\u201037 (IL\u201037), an anti\u2010inflammatory cytokine, has recently been shown to modulate immune responses and enhance NK\u2010cell activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Liver mononuclear cells were isolated from 24 deceased donors. For functional experiments, liver NK cells from six donors were cultured with interleukin\u20102 (IL\u20102) in the presence or absence of IL\u201037. Flow cytometry was used to evaluate activation markers, and cytotoxicity assays assessed NK cell\u2013mediated tumor lysis. Serum IL\u201033 and IL\u201037 levels were measured in 120 patients undergoing liver resection for HCC, and their associations with oncological outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u201037 significantly enhanced NK\u2010cell cytotoxicity, increasing TRAIL and NKp44 expression. Clinically, patients with higher serum IL\u201037 levels showed improved 5\u2010year recurrence\u2010free survival (35.5% vs. 20.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and a lower incidence of early recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201037 enhanced liver NK\u2010cell cytotoxicity in experimental analyses, and higher preoperative serum IL\u201037 levels were associated with improved recurrence\u2010free survival after liver resection for HCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70178","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:11:26Z","timestamp":1788513086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin\u201037 Enhances Liver\n                    <scp>NK<\/scp>\n                    Cell Cytotoxicity and Improves Recurrence\u2010Free Survival in Hepatocellular Carcinoma Patients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-5341","authenticated-orcid":false,"given":"Yuki","family":"Imaoka","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"},{"name":"Division of Abdominal Transplant, Department of Surgery Stanford University School of Medicine  Stanford California 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