{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:03:22Z","timestamp":1790766202413,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Liver transplantation (LT) and liver resection (LR) are curative options for early\u2010stage hepatocellular carcinoma (HCC), but the optimal approach for single\u2010nodule disease remains debated. This systematic review and meta\u2010analysis compared long\u2010term outcomes of LT versus LR in patients with single\u2010nodule HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed and Cochrane Library were searched (2012\u20132023) following PRISMA guidelines. Studies comparing LT and LR in adults with single\u2010nodule HCC were included. Overall survival (OS) and disease\u2010free survival (DFS) at 1, 3, 5, and 10\u2009years were analyzed using random\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight studies including 5094 patients (LT: 2289; LR: 2805) were analyzed. No randomized clinical trials were identified. LT showed significantly higher OS at 3, 5, and 10\u2009years, while 1\u2010year OS was similar. DFS was superior in the LT group at all time points, with progressively larger benefits over time. ITT and tumor\u2010size sensitivity analyses showed similar findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LT was associated with better long\u2010term OS and DFS than LR in patients with single\u2010nodule HCC. The consistency of these findings, particularly for DFS, suggests a potential oncological benefit of LT in appropriately selected patients. However, the observational design and substantial baseline differences limit causal interpretation and warrant further comparative research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>This study was registered prospectively in the International Prospective Register of Systematic Reviews (PROSPERO) under the ID number CRD42024512589.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70182","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:24:11Z","timestamp":1790763851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver Transplantation Versus Resection for Single\u2010Nodule Hepatocellular Carcinoma: A Systematic Review and 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