{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:03:27Z","timestamp":1789974207374,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Purpose<\/jats:title>\n                    <jats:p>Postoperative pancreatic fistula (POPF) is a common complication after pancreatic surgery and its mechanisms remain incompletely understood. While the diameter of the main pancreatic duct is well\u2010known to be a risk factor of POPF, the impact of branch duct's (BD) anatomy is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive pancreas procured from body donations were prospectively studied between March 2024 and March 2025. After total pancreatectomy, the main pancreatic and accessory ducts, when present, were cannulated and injected with polymerizable resin. Tissue corrosion using potassium hydroxide produced detailed 3D casts. BD were analyzed according to number, order, and angulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty 3D casts were analyzed from donors. The median number of BD was 96\u2009\u00b1\u200927, including 45\u2009\u00b1\u20098 first\u2010order BD. Pancreatic heads exhibited the highest number of BD, while the isthmus showed the fewest (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Mean angulation increased progressively from 74\u00b0\u2009\u00b1\u200914\u00b0 in the isthmus to 81\u00b0\u2009\u00b1\u200912\u00b0 in the tail (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.351). Ductal bifurcation of the main pancreatic duct at the corporeocaudal junction was present in 17%. The cephalic and uncinate regions displayed the most complex networks and included long ascending and descending branches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pancreatic ductal network shows substantial regional variability, which may partly explain differences in POPF risk according to the transection site.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70191","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:32:47Z","timestamp":1789972367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Hidden Architecture of Pancreatic Ducts: 3D Anatomical Reconstruction and Its Implication on Pancreatic Resection"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-7245","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Frey","sequence":"first","affiliation":[{"name":"University C\u00f4te d'Azur  Nice France"},{"name":"Department of Digestive Surgery, Pasteur Hospital University Hospital of Nice  Nice France"},{"name":"Epione Team Universit\u00e9 C\u00f4te d'Azur, Inria  Nice France"},{"name":"Facult\u00e9 de M\u00e9decine, Institut d'Anatomie Normale Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9990-5739","authenticated-orcid":false,"given":"Luisa","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Institut d'Anatomie Normale Universit\u00e9 C\u00f4te d'Azur  Nice France"},{"name":"Facult\u00e9 de M\u00e9decine, Institut Universitaire d'Anthropologie M\u00e9dico\u2010L\u00e9gale Universit\u00e9 C\u00f4te d'Azur  Nice France"},{"name":"Unit\u00e9 de recherche clinique C\u00f4te d'Azur (UR2CA) Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Gaujoux","sequence":"additional","affiliation":[{"name":"Digestive, Hepatobiliary, Pancreatic and Endocrine Surgery Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Manai","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Institut d'Anatomie Normale Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Pimont","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Institut d'Anatomie Normale Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Baqu\u00e9","sequence":"additional","affiliation":[{"name":"University C\u00f4te d'Azur  Nice France"},{"name":"Department of Digestive Surgery, Pasteur Hospital University Hospital of Nice  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-2260","authenticated-orcid":false,"given":"Michel","family":"Rayar","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Pasteur Hospital University Hospital of Nice  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bronsard","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Institut d'Anatomie Normale Universit\u00e9 C\u00f4te d'Azur  Nice France"},{"name":"Unit\u00e9 de recherche clinique C\u00f4te d'Azur (UR2CA) Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7436-5999","authenticated-orcid":false,"given":"Alain","family":"Sauvanet","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Bilio\u2010Pancreatic Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris University Paris Cit\u00e9  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Baqu\u00e9","sequence":"additional","affiliation":[{"name":"University C\u00f4te d'Azur  Nice France"},{"name":"Department of Digestive Surgery, Pasteur Hospital University Hospital of Nice  Nice France"},{"name":"Facult\u00e9 de M\u00e9decine, Institut d'Anatomie Normale Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2017.01.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.11.014"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2024.05.043"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010007\u20109388\u20105"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010017\u20104263\u20105"},{"key":"e_1_2_11_6_1","volume-title":"Encyclopedia of Tissue Engineering and Regenerative Medicine","author":"Spencer R. A.","year":"2019"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000007642"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.337125014"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091390109"},{"key":"e_1_2_11_10_1","first-page":"43","article-title":"Studies on the Retrograde Pancreatography in Autopsy Specimens","volume":"24","author":"Ishibashi T.","year":"1977","journal-title":"Bulletin of Tokyo Medical and Dental University"},{"key":"e_1_2_11_11_1","unstructured":"\u201cDecree No. 2022\u2010719 of April 27 2022 on Body Donation for Medical Teaching and Research Purposes \u201dhttps:\/\/www.legifrance.gouv.fr\/eli\/decret\/2022\/4\/27\/ESRS2204519D\/jo\/texte."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anuro.2005.12.003"},{"issue":"2","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0039-6060(99)70263-1","article-title":"Spatial Arrangement of the Pancreatic Ducts in the Head of the Pancreas With Special Reference to the Branches of the Uncinate Process","volume":"125","author":"Takahashi S.","year":"1999","journal-title":"Surgery"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049441"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002620"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005497"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231983"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010011\u20101253\u2010x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010009\u20100526\u20104"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae039"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.596580"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(11)60237\u20107"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010012\u20101963\u2010x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9747421"},{"issue":"4","key":"e_1_2_11_25_1","first-page":"639","article-title":"Bifurcation of the Main Pancreatic Duct in the Body of the Pancreas. Two Case Reports and Literature Study of a Rare Anatomical Variant of the Pancreatic Duct","volume":"83","author":"Krott L.","year":"2020","journal-title":"Acta Gastro\u2010Enterologica Belgica"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000601"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2025.109442"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244\u2010016\u20100517\u20102"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.70191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhbp.70191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.70191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:32:49Z","timestamp":1789972369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.70191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":28,"alternative-id":["10.1002\/jhbp.70191"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.70191","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]},"assertion":[{"value":"2026-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jhbp.70191"}}