{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:50:45Z","timestamp":1791802245458,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Perihilar cholangiocarcinoma (pCCA) is an aggressive biliary malignancy usually requiring major hepatectomy, which carries substantial morbidity and mortality. In selected patients with Bismuth\u2010Corlette Type I\u2013II tumors, isolated extrahepatic bile duct resection (EH) may represent a parenchyma\u2010preserving alternative. However, comparative outcome data remain limited. This study evaluated perioperative and long\u2010term outcomes following EH and major hepatectomy (MH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Of 305 consecutive patients undergoing surgery for perihilar cholangiocarcinoma between 2010 and 2024, 49 with the uncommon Bismuth\u2010Corlette Type I\u2013II disease met the inclusion criteria and underwent either major hepatectomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926) or extrahepatic bile duct resection (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) with lymphadenectomy. Surgical selection was based on liver function, comorbidities, and tumor extent. Perioperative outcomes and overall survival were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EH patients were older (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and had more hepatic comorbidities (21.7% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). MH was associated with more severe complications (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). R0 resection rates were similar (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.88). One\u2010, three\u2010, and five\u2010year overall survival did not differ significantly (EH: 82%, 47%, 24%; MH: 72%, 47%, 27%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.472).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MH remains the standard treatment for medically fit patients with pCCA. In carefully selected, high\u2010risk patients with anatomically limited Bismuth\u2010Corlette Type I\u2013II tumors, isolated EH may provide lower perioperative morbidity while achieving acceptable long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.70198","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:40:46Z","timestamp":1791801646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Extrahepatic Bile Duct Resection as a Parenchyma\u2010Preserving Alternative in Bismuth I\u2013\n                    <scp>II<\/scp>\n                    Perihilar Cholangiocarcinoma: A Comparative Single\u2010Center Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-9151","authenticated-orcid":false,"given":"Eriselda","family":"Keshi","sequence":"first","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health (BIH)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-4788","authenticated-orcid":false,"given":"Simon","family":"Moosburner","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health (BIH)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5506-8741","authenticated-orcid":false,"given":"Florian","family":"Siemund","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8149-4011","authenticated-orcid":false,"given":"Nils","family":"Haep","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Malinka","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uli","family":"Fehrenbach","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzel","family":"Sch\u00f6ning","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Pratschke","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Cluster of Excellence Matters of Activity. Image Space Material Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Under Germany's Excellence Strategy \u2010 EXC 2025 \u2013 390648296  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0593-9917","authenticated-orcid":false,"given":"Felix","family":"Krenzien","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health (BIH)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"issue":"6","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jhep.2022.07.022","article-title":"Current Epidemiology of Cholangiocarcinoma in Western Countries","volume":"77","author":"Vithayathil M.","year":"2022","journal-title":"Journal of Hepatology"},{"issue":"1","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00000658-199201000-00005","article-title":"Management Strategies in Resection for Hilar Cholangiocarcinoma","volume":"215","author":"Bismuth H.","year":"1992","journal-title":"Annals of Surgery"},{"issue":"8","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S2468-1253(24)00095-5","article-title":"Durvalumab or Placebo Plus Gemcitabine and Cisplatin in Participants With Advanced Biliary Tract Cancer (TOPAZ\u20101): Updated Overall Survival From a Randomised Phase 3 Study","volume":"9","author":"Oh D. 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The Milan Jury\u2010Based Consensus","author":"Pfister M.","year":"2025","journal-title":"Annals of Surgery"},{"issue":"7","key":"e_1_2_13_21_1","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1245\/s10434-024-15115-0","article-title":"Higher Postoperative Mortality and Inferior Survival After Right\u2010Sided Liver Resection for Perihilar Cholangiocarcinoma: Left\u2010Sided Resection Is Preferred When Possible","volume":"31","author":"Olthof P. 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