{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:56:51Z","timestamp":1791997011408,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      This study aims to define the role of flurodeoxyglucose (\n                      <jats:sup>18F<\/jats:sup>\n                      \u2010FDG) positron emission tomography\u2010contrast enhanced computed tomography (PETCECT) scan in upstaging disease in patients with locally advanced gallbladder cancer (LAGBC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An analysis of a prospectively maintained database of gallbladder cancer (GBC) patients was performed. Patients found to have locally advanced (T3 and\/or T4 or N+) but non\u2010metastatic disease on initial imaging, either a contrast enhanced computed tomography (CECT) or a magnetic resonance imaging (MRI) scan, underwent an additional PETCECT for staging and the results impacting treatment decision were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and three patients of LAGBC underwent CECT\/MRI and PETCECT. 48\/103 (46.6%) were found to be upstaged to stage IV after PETCECT. The most common metastatic site was non\u2010regional retroperitoneal lymph nodes (12 patients, 11.7%) followed by satellite lesions in liver (11, 10.7%). Fourteen (13.6%) patients had equivocal findings on PET scan that required confirmation by tissue sampling out of which 10 (71.4%) were subsequently found to have metastatic disease. The only statistically significant factor predicting distant spread on PETCECT was the presence of loco\u2010regional nodes on CT scan (odds ratio\u00a06.15,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PETCECT is a valuable tool to rule out metastatic disease in patients presenting with LAGBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.712","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T13:37:34Z","timestamp":1579181854000},"page":"164-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Role of positron emission tomography\u2010contrast enhanced computed tomography in locally advanced gallbladder cancer"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-6825","authenticated-orcid":false,"given":"Shraddha","family":"Patkar","sequence":"first","affiliation":[{"name":"Gastrointestinal and Hepatopancreaticobiliary Services Department of Surgical Oncology Tata Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6215-3123","authenticated-orcid":false,"given":"Aditi","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Hepatopancreaticobiliary Services Department of Surgical Oncology Tata Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7510-1573","authenticated-orcid":false,"given":"Mahesh","family":"Goel","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Hepatopancreaticobiliary Services Department of Surgical Oncology Tata Memorial 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