{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:06:46Z","timestamp":1777511206602,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871461"],"award-info":[{"award-number":["81871461"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to investigate whether portal level of high\u2010mobility group protein B1 (HMGB1) is associated with hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 127 consecutive patients who underwent TIPS and collected portal and peripheral blood samples in our department from December 2017 to May 2019. HMGB1 levels were determined using enzyme\u2010linked immunosorbent assay kits. HMGB1 and other HE related parameters were estimated by competing risk analysis, receiver operating characteristic (ROC) analysis and Kaplan\u2013Meier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with HE after TIPS were older (<jats:italic>P<\/jats:italic> = .019) and had higher portal HMGB1 level (<jats:italic>P<\/jats:italic> = .038) than those without. Univariate competing risk analysis: age (sHR 1.025, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026), hepatorenal syndrome (sHR 3.149, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010), model for end\u2010of\u2010stage liver disease (MELD) score (sHR 1.055, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.024), prior HE (sHR 4.029, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0005), portal HMGB1 before TIPS (sHR 1.177, <jats:italic>P<\/jats:italic> = .001) reached statistical significance. Multivariate analysis: age (sHR 1.025, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.037), MELD score (sHR 1.062, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011), prior HE (sHR 2.492, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.030) and portal HMGB1 level before TIPS (sHR 1.217, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0002) were significantly different. ROC analyses and Kaplan\u2013Meier curve showed portal HMGB1 level changes before and after TIPS (\u0394HMGB1) had good predictive value in the cut\u2010off 0.012 ng\/mL (AUC\u00a0=\u00a00.748, <jats:italic>P<\/jats:italic> &lt; .001, Sensitivity\u00a0=\u00a00.743, Specificity\u00a0=\u00a00.655).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Portal HMGB1 may be a therapeutic target for post\u2010TIPS HE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.770","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T12:52:42Z","timestamp":1590670362000},"page":"522-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010mobility group protein B1: A predictive biomarker for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-9360","authenticated-orcid":false,"given":"Quan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Interventional Therapy Peking University Ninth School of Clinical Medicine Beijing Shijitan Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Ninth School of Clinical Medicine Beijing Shijitan Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Dong","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Ninth School of Clinical Medicine Beijing Shijitan Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Ninth School of Clinical Medicine Beijing Shijitan Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Ninth School of Clinical Medicine Beijing Shijitan Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Hua","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Ninth School of Clinical Medicine Beijing Shijitan Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu\u2010Quan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking 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