{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:46:00Z","timestamp":1770284760951,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have focused on the risk factors for dysfunction of endoscopic biliary drainage (EBD) in preoperative patients with malignant hilar biliary obstruction (MHBO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the database between February 2011 and December 2018 and identified patients with MHBO who underwent radical operation. The rate of dysfunction of the initial EBD, risk factors for dysfunction of the initial EBD and survival after surgery were retrospectively evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed a total of 131 patients [95 males (72.5%); mean age, 69.5 (\u00b17.3) years; Bismuth\u2010Corlette classification (BC) I\/II\/IIIa\/IIIb\/IV, 50\/26\/22\/17\/16; hilar cholangiocarcinoma\/gall bladder cancer, 115\/16]. Dysfunction of the initial EBD occurred in 28 patients (21.4%). The cumulative incidences of dysfunction of the initial EBD in all patients were 18.4%, 38.2% and 47.0% at 30, 60 and 90\u00a0days, respectively (Kaplan\u2013Meier method). The rate of dysfunction of the initial EBD increased in patients with BC\u2010IV (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Multivariate analysis showed that BC\u2010IV and pre\u2010EBD cholangitis were significantly associated with the occurrence of dysfunction of the initial EBD. Survival rates were not significantly different according to the initial biliary drainage methods and presence\/absence of the initial EBD dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dysfunction of the initial EBD frequently occurs in patients with the BC\u2010IV and those with pre\u2010EBD cholangitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.778","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T14:47:30Z","timestamp":1591541250000},"page":"851-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors for dysfunction of preoperative endoscopic biliary drainage for malignant hilar biliary obstruction"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4156-8025","authenticated-orcid":false,"given":"Ryo","family":"Sugiura","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Faculty of Medicine Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-6068","authenticated-orcid":false,"given":"Masaki","family":"Kuwatani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Faculty of Medicine Graduate School of Medicine Hokkaido University Sapporo Japan"},{"name":"Division of Endoscopy Hokkaido University Hospital Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Faculty of Medicine Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumichi","family":"Kawakubo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Faculty of Medicine Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Kamachi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery I Faculty of Medicine Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Taketomi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery I Faculty of Medicine Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Noji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery II Faculty of Medicine Graduate School of Medicine Hokkaido University Sapporo 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