{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:14:49Z","timestamp":1758705289208,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The TNM (Tumor, Node, Metastasis) classification of the 8th Union for International Cancer Control and the 6th Japanese classification of biliary tract cancer were made on the premise that the prognostic effect of each regional lymph node station is similar. However, some studies have reported different effects of lymph node metastasis location on post\u2010resection prognosis. This study aimed to investigate outcome following radical resection of ampullary carcinoma according to station of lymph node metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent surgical resection for ampullary carcinoma between January 2007 and December 2017 at two separate Japanese institutions were included. Regional lymph nodes were subclassified as follows: Pancreatoduodenal lymph nodes (PD) and others (OT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 101 patients analyzed, 34 had regional lymph node metastasis. OT metastasis was found in eight patients. Significant differences were found in relapse\u2010free survival (RFS) and overall survival (OS) between the three study groups (no nodal metastasis, only PD metastasis and OT metastasis; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 for both). OT metastasis was an independent prognostic factor in the multivariate analysis for RFS (hazard ratio [HR] 17.14; 95% confidence interval [CI], 6.33\u201043.93) and OS (HR 11.06; 95% CI, 3.7\u201032.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The poor prognosis of ampullary carcinoma patients with OT metastasis suggests that regional lymph nodes should not be categorized equally into one group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.791","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:17:25Z","timestamp":1592957845000},"page":"712-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic significance of regional lymph node metastasis according to station in ampullary carcinoma"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-2564","authenticated-orcid":false,"given":"Keita","family":"Tashiro","sequence":"first","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Kuroki","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Cancer Institute Hospital Koto Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Einama","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-4477","authenticated-orcid":false,"given":"Yoichi","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suefumi","family":"Aosasa","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"},{"name":"Department of Surgery Shin\u2010Kuki General Hospital Kuki Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Cancer Institute Hospital Koto Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-023X","authenticated-orcid":false,"given":"Yu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Cancer Institute Hospital Koto Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Hase","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"},{"name":"Department of Gastrointestinal Surgery Ibaraki Prefectural Central Hospital Kasama Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Kishi","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-008-0015-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.04.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.7.718"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9537-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199807000-00013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199806000-00005"},{"volume-title":"International Union Against Cancer (UICC). Prognostic TNM Classification of Malignant Tumours","year":"2017","author":"Brierley JD","key":"e_1_2_7_8_1"},{"volume-title":"General Rules for Clinical and Pathological Studies on Cancer of the Biliary Tract","year":"2013","author":"Japanese Society of Hepato\u2010Biliary\u2010Pancreatic Surgery","key":"e_1_2_7_9_1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481107700322"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.10.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21283"},{"key":"e_1_2_7_13_1","first-page":"1693","article-title":"Carcinoma of the ampulla of Vater. Is radical lymphadenectomy beneficial to patients with nodal disease?","volume":"82","author":"Shirai Y","year":"1996","journal-title":"J Surg Oncol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90048-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001065"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00012257"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.5.526"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.6.529"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1991.01410270099016"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000220864.80034.63"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800821235"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24281"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.07.512"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.08.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"volume-title":"Classification of Biliary Tract Carcinoma","year":"2003","author":"Japanese Society of Biliary Surgery","key":"e_1_2_7_26_1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1417474"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9752"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(89)90201-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800840734"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.04.007"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjhbp.791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhbp.791","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T04:05:22Z","timestamp":1693800322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,30]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/jhbp.791"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.791","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"type":"print","value":"1868-6974"},{"type":"electronic","value":"1868-6982"}],"subject":[],"published":{"date-parts":[[2020,7,30]]},"assertion":[{"value":"2020-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}